4jv8: Difference between revisions
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==The crystal structure of PDE6D in complex with rac-S1== | ==The crystal structure of PDE6D in complex with rac-S1== | ||
<StructureSection load='4jv8' size='340' side='right' caption='[[4jv8]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='4jv8' size='340' side='right'caption='[[4jv8]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4jv8]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4jv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JV8 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1M1:(6R)-6-(PYRIDIN-2-YL)-5,6-DIHYDROBENZIMIDAZO[1,2-C]QUINAZOLINE'>1M1</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jv8 OCA], [https://pdbe.org/4jv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jv8 RCSB], [https://www.ebi.ac.uk/pdbsum/4jv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jv8 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4jv8" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Phosphodiesterase|Phosphodiesterase]] | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bastiaens | [[Category: Large Structures]] | ||
[[Category: Chandra | [[Category: Bastiaens P]] | ||
[[Category: Gunther | [[Category: Chandra A]] | ||
[[Category: Hahn | [[Category: Gunther Z]] | ||
[[Category: Hoffmann | [[Category: Hahn S]] | ||
[[Category: Ismail | [[Category: Hoffmann M]] | ||
[[Category: Papke | [[Category: Ismail S]] | ||
[[Category: Triola | [[Category: Papke B]] | ||
[[Category: Vartak | [[Category: Triola G]] | ||
[[Category: Waldmann | [[Category: Vartak N]] | ||
[[Category: Wittinghofer | [[Category: Waldmann H]] | ||
[[Category: Wittinghofer A]] | |||