4q1f: Difference between revisions

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 ==Human dCK C4S-S74E mutant in complex with UDP and the inhibitor 12R {N-{2-[5-(4-{(1R)-1-[(4,6-diaminopyrimidin-2-yl)sulfanyl]ethyl}-5-methyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide}==
-<StructureSection load='4q1f' size='340' side='right' caption='[[4q1f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='4q1f' size='340' side='right'caption='[[4q1f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4q1f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1F FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4q1f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q1F FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XN:N-{2-[5-(4-{(1R)-1-[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]ETHYL}-5-METHYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]ETHYL}METHANESULFONAMIDE'>2XN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q18|4q18]], [[4q19|4q19]], [[4q1a|4q1a]], [[4q1b|4q1b]], [[4q1c|4q1c]], [[4q1d|4q1d]], [[4q1e|4q1e]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2XN:N-{2-[5-(4-{(1R)-1-[(4,6-DIAMINOPYRIMIDIN-2-YL)SULFANYL]ETHYL}-5-METHYL-1,3-THIAZOL-2-YL)-2-METHOXYPHENOXY]ETHYL}METHANESULFONAMIDE'>2XN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Deoxycytidine_kinase Deoxycytidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.74 2.7.1.74] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1f OCA], [https://pdbe.org/4q1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q1f RCSB], [https://www.ebi.ac.uk/pdbsum/4q1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q1f ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q1f RCSB], [http://www.ebi.ac.uk/pdbsum/4q1f PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN]] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
+[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4q1f" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Deoxycytidine kinase 3D structures|Deoxycytidine kinase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Deoxycytidine kinase]]
+[[Category: Homo sapiens]]
-[[Category: Lavie, A]]
+[[Category: Large Structures]]
-[[Category: Nomme, J]]
+[[Category: Lavie A]]
-[[Category: Deoxycytidine]]
+[[Category: Nomme J]]
-[[Category: Inhibitor complex]]
-[[Category: Kinase]]
-[[Category: Phosphoryl transfer]]
-[[Category: Phosphorylation]]
-[[Category: Transferase]]
-[[Category: Transferase-transferase inhibitor complex]]