2ec7: Difference between revisions

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-[[Image:2ec7.jpg|left|200px]]
- {{Structure
+==Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein==
-|PDB= 2ec7 |SIZE=350|CAPTION= <scene name='initialview01'>2ec7</scene>
+<StructureSection load='2ec7' size='340' side='right'caption='[[2ec7]]' scene=''>
-|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+50'>AC1</scene> and <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+51'>AC2</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
+<table><tr><td colspan='2'>[[2ec7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_2_(ISOLATE_GHANA-1) Human immunodeficiency virus type 2 (ISOLATE GHANA-1)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EC7 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ec7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ec7 OCA], [https://pdbe.org/2ec7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ec7 RCSB], [https://www.ebi.ac.uk/pdbsum/2ec7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ec7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GAG_HV2G1 GAG_HV2G1] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity).  Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).  p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ec/2ec7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ec7 ConSurf].
+<div style="clear:both"></div>
-'''Solution Structure of Human Immunodificiency Virus Type-2 Nucleocapsid Protein'''
+==See Also==
+*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-EC7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EC7 OCA].
+[[Category: Large Structures]]
-[[Category: Human immunodeficiency virus 1]]
+[[Category: Endoh H]]
-[[Category: Single protein]]
+[[Category: Kodera Y]]
-[[Category: Endoh, H.]]
+[[Category: Kohno T]]
-[[Category: Kodera, Y.]]
+[[Category: Komatsu H]]
-[[Category: Kohno, T.]]
+[[Category: Maeda T]]
-[[Category: Komatsu, H.]]
+[[Category: Matsui T]]
-[[Category: Maeda, T.]]
+[[Category: Miyauchi E]]
-[[Category: Matsui, T.]]
+[[Category: Tanaka H]]
-[[Category: Miyauchi, E.]]
+[[Category: Tanaka T]]
-[[Category: Tanaka, H.]]
-[[Category: Tanaka, T.]]
-[[Category: ZN]]
-[[Category: hiv-2]]
-[[Category: nucleocapsid protein]]
-[[Category: rna recognition]]
-[[Category: viral protein]]
-[[Category: zinc finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:38:07 2008''