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[[Image:2ebj.jpg|left|200px]]


{{Structure
==Crystal structure of pyrrolidone carboxyl peptidase from Thermus thermophilus==
|PDB= 2ebj |SIZE=350|CAPTION= <scene name='initialview01'>2ebj</scene>, resolution 1.90&Aring;
<StructureSection load='2ebj' size='340' side='right'caption='[[2ebj]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2ebj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EBJ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Pyroglutamyl-peptidase_I Pyroglutamyl-peptidase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.3 3.4.19.3]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE= TTHA0888 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ebj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ebj OCA], [https://pdbe.org/2ebj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ebj RCSB], [https://www.ebi.ac.uk/pdbsum/2ebj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ebj ProSAT], [https://www.topsan.org/Proteins/RSGI/2ebj TOPSAN]</span></td></tr>
}}
</table>
 
== Function ==
'''Crystal structure of pyrrolidone carboxyl peptidase from Thermus thermophilus'''
[https://www.uniprot.org/uniprot/Q5SJW4_THET8 Q5SJW4_THET8] Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity).[SAAS:SAAS016125_004_005679]
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2EBJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EBJ OCA].
  <jmolCheckbox>
[[Category: Pyroglutamyl-peptidase I]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eb/2ebj_consurf.spt"</scriptWhenChecked>
[[Category: Single protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Thermus thermophilus]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Agari, Y.]]
  </jmolCheckbox>
[[Category: Karthe, P.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ebj ConSurf].
[[Category: Kumarevel, T S.]]
<div style="clear:both"></div>
[[Category: Kuramitsu, S.]]
__TOC__
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
</StructureSection>
[[Category: Yokoyama, S.]]
[[Category: Large Structures]]
[[Category: degradation of proteins and peptide]]
[[Category: Thermus thermophilus HB8]]
[[Category: hydrolase]]
[[Category: Agari Y]]
[[Category: national project on protein structural and functional analyse]]
[[Category: Karthe P]]
[[Category: nppsfa]]
[[Category: Kumarevel TS]]
[[Category: pyrrolidone carboxyl peptidase]]
[[Category: Kuramitsu S]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: Yokoyama S]]
[[Category: rsgi]]
[[Category: structural genomic]]
[[Category: thermus thermophilus]]
[[Category: ttha0888]]
 
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