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==Structural and biochemical characterization of ClfB:ligand interactions==
==Structural and biochemical characterization of ClfB:ligand interactions==
<StructureSection load='3asw' size='340' side='right' caption='[[3asw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3asw' size='340' side='right'caption='[[3asw]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3asw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ASW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ASW FirstGlance]. <br>
<table><tr><td colspan='2'>[[3asw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ASW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ASW FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3at0|3at0]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">clfB, SA2423 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3asw OCA], [https://pdbe.org/3asw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3asw RCSB], [https://www.ebi.ac.uk/pdbsum/3asw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3asw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3asw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3asw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3asw RCSB], [http://www.ebi.ac.uk/pdbsum/3asw PDBsum]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN] Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLFB_STAAN CLFB_STAAN]] Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps (By similarity).
[https://www.uniprot.org/uniprot/K1C10_HUMAN K1C10_HUMAN]  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Staphylococcus aureus]]
[[Category: Homo sapiens]]
[[Category: Ganesh, V K]]
[[Category: Large Structures]]
[[Category: Adhesin]]
[[Category: Staphylococcus aureus subsp. aureus N315]]
[[Category: Cell adhesion]]
[[Category: Ganesh VK]]
[[Category: Cytokeratin]]
[[Category: Igg like]]

Latest revision as of 18:54, 4 October 2023

Structural and biochemical characterization of ClfB:ligand interactionsStructural and biochemical characterization of ClfB:ligand interactions

Structural highlights

3asw is a 2 chain structure with sequence from Homo sapiens and Staphylococcus aureus subsp. aureus N315. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

K1C10_HUMAN Congenital reticular ichthyosiform erythroderma;Annular epidermolytic ichthyosis;Epidermolytic ichthyosis. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

K1C10_HUMAN

See Also

3asw, resolution 2.60Å

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