2kgr: Difference between revisions

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 ==Solution structure of protein ITSN1 from Homo sapiens. Northeast Structural Genomics Consortium target HR5524A==
-<StructureSection load='2kgr' size='340' side='right' caption='[[2kgr]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2kgr' size='340' side='right'caption='[[2kgr]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2kgr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGR FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ITSN1, ITSN, SH3D1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [http://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [http://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgr OCA], [https://pdbe.org/2kgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgr RCSB], [https://www.ebi.ac.uk/pdbsum/2kgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgr ProSAT], [https://www.topsan.org/Proteins/NESGC/2kgr TOPSAN]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
+[https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgr_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgr ConSurf].
 <div style="clear:both"></div>
+==See Also==
+*[[Intersectin|Intersectin]]
 == References ==
 <references/>
@@ Line 23: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Acton, T]]
+[[Category: Large Structures]]
-[[Category: Ciccosanti, C]]
+[[Category: Acton T]]
-[[Category: Everett, J]]
+[[Category: Ciccosanti C]]
-[[Category: Ghosh, A]]
+[[Category: Everett J]]
-[[Category: Hua, J]]
+[[Category: Ghosh A]]
-[[Category: Jiang, M]]
+[[Category: Hua J]]
-[[Category: Montelione, G]]
+[[Category: Jiang M]]
-[[Category: Structural genomic]]
+[[Category: Montelione G]]
-[[Category: Shastry, R]]
+[[Category: Shastry R]]
-[[Category: Swapna, G]]
+[[Category: Swapna G]]
-[[Category: Szyperski, T]]
+[[Category: Szyperski T]]
-[[Category: Wu, Y]]
+[[Category: Wu Y]]
-[[Category: Xiao, R]]
+[[Category: Xiao R]]
-[[Category: Zhang, Q]]
+[[Category: Zhang Q]]
-[[Category: Cell junction]]
-[[Category: Cell projection]]
-[[Category: Endocytosis]]
-[[Category: Membrane]]
-[[Category: Nesg]]
-[[Category: Phosphoprotein]]
-[[Category: Protein binding]]
-[[Category: PSI, Protein structure initiative]]
-[[Category: Sh3 domain]]
-[[Category: Synapse]]
-[[Category: Synaptosome]]