2dml: Difference between revisions

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-[[Image:2dml.gif|left|200px]]
- {{Structure
+==The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6==
-|PDB= 2dml |SIZE=350|CAPTION= <scene name='initialview01'>2dml</scene>
+<StructureSection load='2dml' size='340' side='right'caption='[[2dml]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2dml]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DML OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DML FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/Protein_disulfide-isomerase Protein disulfide-isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.4.1 5.3.4.1]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE= Pdia6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dml OCA], [https://pdbe.org/2dml PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dml RCSB], [https://www.ebi.ac.uk/pdbsum/2dml PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dml ProSAT], [https://www.topsan.org/Proteins/RSGI/2dml TOPSAN]</span></td></tr>
-}}
+</table>
+== Function ==
-'''The solution structure of the first thioredoxin domain of mouse Protein disulfide-isomerase A6'''
+[https://www.uniprot.org/uniprot/PDIA6_MOUSE PDIA6_MOUSE] May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-DML is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DML OCA].
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dm/2dml_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dml ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Protein disulfide-isomerase]]
+[[Category: Inoue M]]
-[[Category: Single protein]]
+[[Category: Kigawa T]]
-[[Category: Inoue, M.]]
+[[Category: Koshiba S]]
-[[Category: Kigawa, T.]]
+[[Category: Tochio N]]
-[[Category: Koshiba, S.]]
+[[Category: Yokoyama S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
-[[Category: Tochio, N.]]
-[[Category: Yokoyama, S.]]
-[[Category: endoplasmic reticulum]]
-[[Category: isomerase]]
-[[Category: national project on protein structural and functional analyse]]
-[[Category: nppsfa]]
-[[Category: redox-active center]]
-[[Category: riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
-[[Category: structural genomic]]
-[[Category: thioredoxin domain-containing protein 7]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:28:57 2008''