3me3: Difference between revisions

<StructureSection load='3me3' size='340' side='right'caption='[[3me3]], [[Resolution|resolution]] 1.95&Aring;' scene=''>

<table><tr><td colspan='2'>[[3me3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ME3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ME3 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SZ:3-{[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-1,4-DIAZEPAN-1-YL]SULFONYL}ANILINE'>3SZ</scene>, <scene name='pdbligand=FBP:BETA-FRUCTOSE-1,6-DIPHOSPHATE'>FBP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3me3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3me3 OCA], [https://pdbe.org/3me3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3me3 RCSB], [https://www.ebi.ac.uk/pdbsum/3me3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3me3 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/KPYM_HUMAN KPYM_HUMAN] Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.<ref>PMID:17308100</ref> <ref>PMID:18191611</ref> <ref>PMID:21620138</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/3me3_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3me3 ConSurf].

*[[Pyruvate kinase 3D structures|Pyruvate kinase 3D structures]]

[[Category: Large Structures]]

[[Category: Arrowsmith CH]]

[[Category: Auld D]]

[[Category: Bochkarev A]]

[[Category: Bountra C]]

[[Category: Boxer M]]

[[Category: Dimov S]]

[[Category: Edwards AM]]

[[Category: Hong B]]

[[Category: Inglese J]]

[[Category: Jianq J-K]]

[[Category: Min S]]

[[Category: Park H]]

[[Category: Skoumbourdis A]]

[[Category: Southall N]]

[[Category: Tempel W]]

[[Category: Thomas C]]

[[Category: Weigelt J]]