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[[Image:2cz0.gif|left|200px]]


{{Structure
==photo-activation state of Fe-type NHase in aerobic condition==
|PDB= 2cz0 |SIZE=350|CAPTION= <scene name='initialview01'>2cz0</scene>, resolution 1.50&Aring;
<StructureSection load='2cz0' size='340' side='right'caption='[[2cz0]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=BUA:BUTANOIC ACID'>BUA</scene>
<table><tr><td colspan='2'>[[2cz0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CZ0 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Nitrile_hydratase Nitrile hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.84 4.2.1.84]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BUA:BUTANOIC+ACID'>BUA</scene>, <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cz0 OCA], [https://pdbe.org/2cz0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cz0 RCSB], [https://www.ebi.ac.uk/pdbsum/2cz0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cz0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cz0 TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NHAA_RHOER NHAA_RHOER] NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cz/2cz0_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cz0 ConSurf].
<div style="clear:both"></div>


'''photo-activation state of Fe-type NHase in aerobic condition'''
==See Also==
 
*[[Nitrile hydratase|Nitrile hydratase]]
 
__TOC__
==About this Structure==
</StructureSection>
2CZ0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rhodococcus_erythropolis Rhodococcus erythropolis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CZ0 OCA].
[[Category: Large Structures]]
[[Category: Nitrile hydratase]]
[[Category: Protein complex]]
[[Category: Rhodococcus erythropolis]]
[[Category: Rhodococcus erythropolis]]
[[Category: Endo, I.]]
[[Category: Endo I]]
[[Category: Hashimoto, K.]]
[[Category: Hashimoto K]]
[[Category: Kamiya, N.]]
[[Category: Kamiya N]]
[[Category: Kawano, Y.]]
[[Category: Kawano Y]]
[[Category: Nakayama, H.]]
[[Category: Nakayama H]]
[[Category: Odaka, M.]]
[[Category: Odaka M]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Takio K]]
[[Category: Takio, K.]]
[[Category: BUA]]
[[Category: FE]]
[[Category: cysteine-sulfenic acid]]
[[Category: cysteine-sulfinic acid]]
[[Category: hydration]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nitrile]]
[[Category: non-hem iron]]
[[Category: nppsfa]]
[[Category: over-oxidization]]
[[Category: photo-reactive]]
[[Category: post-translational modification]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:21:21 2008''

Latest revision as of 14:32, 22 May 2024

photo-activation state of Fe-type NHase in aerobic conditionphoto-activation state of Fe-type NHase in aerobic condition

Structural highlights

2cz0 is a 2 chain structure with sequence from Rhodococcus erythropolis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

NHAA_RHOER NHase catalyzes the hydration of various nitrile compounds to the corresponding amides. Industrial production of acrylamide is now being developed using some of the enzymes of this class.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2cz0, resolution 1.50Å

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