3fbn: Difference between revisions

<StructureSection load='3fbn' size='340' side='right'caption='[[3fbn]], [[Resolution|resolution]] 3.01&Aring;' scene=''>

<table><tr><td colspan='2'>[[3fbn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FBN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.007&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fbn OCA], [https://pdbe.org/3fbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fbn RCSB], [https://www.ebi.ac.uk/pdbsum/3fbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fbn ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MED7_YEAST MED7_YEAST] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. The Mediator complex unfolds to an extended conformation and partially surrounds RNA polymerase II, specifically interacting with the unphosphorylated form of the C-terminal domain (CTD) of RNA polymerase II. The Mediator complex dissociates from the RNA polymerase II holoenzyme and stays at the promoter when transcriptional elongation begins.<ref>PMID:11555651</ref> <ref>PMID:16076843</ref> <ref>PMID:16263706</ref>  

[[Category: Baumli S]]

[[Category: Cramer P]]

[[Category: Koschubs T]]

[[Category: Kurth F]]

[[Category: Lariviere L]]

[[Category: Martin DE]]

[[Category: Seizl M]]