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==Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase==
==Crystal structure of beta-D-xylosidase from Thermoanaerobacterium saccharolyticum, a family 39 glycoside hydrolase==
<StructureSection load='1uhv' size='340' side='right' caption='[[1uhv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1uhv' size='340' side='right'caption='[[1uhv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1uhv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoanaerobacterium_saccharolyticum Thermoanaerobacterium saccharolyticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1UHV FirstGlance]. <br>
<table><tr><td colspan='2'>[[1uhv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoanaerobacterium_saccharolyticum Thermoanaerobacterium saccharolyticum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UHV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DFX:1,2-DEOXY-2-FLUORO-XYLOPYRANOSE'>DFX</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1px8|1px8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DFX:1,2-DEOXY-2-FLUORO-XYLOPYRANOSE'>DFX</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xylan_1,4-beta-xylosidase Xylan 1,4-beta-xylosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.37 3.2.1.37] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhv OCA], [https://pdbe.org/1uhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uhv RCSB], [https://www.ebi.ac.uk/pdbsum/1uhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uhv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uhv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1uhv RCSB], [http://www.ebi.ac.uk/pdbsum/1uhv PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/XYNB_THESA XYNB_THESA]] Has hydrolytic activity towards xylopentaose, xylotriose, xylobiose and P-nitrophenyl-beta-D-xylopyranoside, but has no activity toward xylan.  
[https://www.uniprot.org/uniprot/XYNB_THESA XYNB_THESA] Has hydrolytic activity towards xylopentaose, xylotriose, xylobiose and P-nitrophenyl-beta-D-xylopyranoside, but has no activity toward xylan.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhv_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uh/1uhv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uhv ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1uhv" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Xylosidase|Xylosidase]]
*[[Xylosidase 3D structures|Xylosidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermoanaerobacterium saccharolyticum]]
[[Category: Thermoanaerobacterium saccharolyticum]]
[[Category: Xylan 1,4-beta-xylosidase]]
[[Category: Ahn HJ]]
[[Category: Ahn, H J]]
[[Category: Berendzen J]]
[[Category: Berendzen, J]]
[[Category: Il Lee B]]
[[Category: Laivenieks, M]]
[[Category: Laivenieks M]]
[[Category: Lee, B Il]]
[[Category: Liong EC]]
[[Category: Liong, E C]]
[[Category: Pedelacq JD]]
[[Category: Pedelacq, J D]]
[[Category: Suh SW]]
[[Category: Suh, S W]]
[[Category: Vieille C]]
[[Category: Vieille, C]]
[[Category: Vocadlo DJ]]
[[Category: Vocadlo, D J]]
[[Category: Withers SG]]
[[Category: Withers, S G]]
[[Category: Yang JK]]
[[Category: Yang, J K]]
[[Category: Yoon HJ]]
[[Category: Yoon, H J]]
[[Category: Zeikus GJ]]
[[Category: Zeikus, G J]]
[[Category: Covalent glycosyl-enzyme intermediate]]
[[Category: Family 39 glycoside hydrolase]]
[[Category: Hydrolase]]
[[Category: Xylan]]
[[Category: Xylose]]
[[Category: Xylosidase]]

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