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==Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid== | ==Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid== | ||
<StructureSection load='4mqb' size='340' side='right' caption='[[4mqb]], [[Resolution|resolution]] 1.55Å' scene=''> | <StructureSection load='4mqb' size='340' side='right'caption='[[4mqb]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4mqb]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4mqb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQB FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mqb OCA], [https://pdbe.org/4mqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mqb RCSB], [https://www.ebi.ac.uk/pdbsum/4mqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mqb ProSAT]</span></td></tr> | ||
< | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/KTHY_STAAM KTHY_STAAM] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). | ||
==See Also== | ==See Also== | ||
*[[Thymidylate kinase|Thymidylate kinase]] | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Staphylococcus aureus subsp. aureus Mu50]] | ||
[[Category: Anderson | [[Category: Anderson WF]] | ||
[[Category: Babnigg | [[Category: Babnigg G]] | ||
[[Category: Filippova | [[Category: Filippova EV]] | ||
[[Category: Jedrzejczak | [[Category: Jedrzejczak R]] | ||
[[Category: Joachimiak | [[Category: Joachimiak A]] | ||
[[Category: Kiryukhina | [[Category: Kiryukhina O]] | ||
[[Category: Minasov G]] | |||
[[Category: Rubin E]] | |||
[[Category: Minasov | [[Category: Sacchettini J]] | ||
[[Category: Rubin | [[Category: Shuvalova L]] | ||
[[Category: Sacchettini | |||
[[Category: Shuvalova | |||
Latest revision as of 19:40, 20 September 2023
Crystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acidCrystal structure of thymidylate kinase from Staphylococcus aureus in complex with 2-(N-morpholino)ethanesulfonic acid
Structural highlights
FunctionKTHY_STAAM Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity). See Also |
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