4x7p: Difference between revisions

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'''Unreleased structure'''


The entry 4x7p is ON HOLD
==Crystal structure of apo S. aureus TarM==
 
<StructureSection load='4x7p' size='340' side='right'caption='[[4x7p]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
Authors: Worrall, L.J., Sobhanifar, S., Gruninger, R.J., Strynadka, N.C.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4x7p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_21178 Staphylococcus aureus subsp. aureus 21178]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X7P FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Gruninger, R.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7p OCA], [https://pdbe.org/4x7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x7p RCSB], [https://www.ebi.ac.uk/pdbsum/4x7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x7p ProSAT]</span></td></tr>
[[Category: Sobhanifar, S]]
</table>
[[Category: Worrall, L.J]]
== Function ==
[[Category: Strynadka, N.C]]
[https://www.uniprot.org/uniprot/TARM_STAAC TARM_STAAC] Attaches N-acetyl-alpha-D-glucosamine residues to poly(RboP)-wall teichoic acids (WTAs).<ref>PMID:20185825</ref> <ref>PMID:25624472</ref> <ref>PMID:25697358</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Staphylococcus aureus subsp. aureus 21178]]
[[Category: Gruninger RJ]]
[[Category: Sobhanifar S]]
[[Category: Strynadka NC]]
[[Category: Worrall LJ]]

Latest revision as of 16:00, 1 March 2024

Crystal structure of apo S. aureus TarMCrystal structure of apo S. aureus TarM

Structural highlights

4x7p is a 2 chain structure with sequence from Staphylococcus aureus subsp. aureus 21178. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.4Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TARM_STAAC Attaches N-acetyl-alpha-D-glucosamine residues to poly(RboP)-wall teichoic acids (WTAs).[1] [2] [3]

References

  1. ↑ Xia G, Maier L, Sanchez-Carballo P, Li M, Otto M, Holst O, Peschel A. Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM. J Biol Chem. 2010 Apr 30;285(18):13405-15. PMID:20185825 doi:10.1074/jbc.M109.096172
  2. ↑ Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC. Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E576-85. doi:, 10.1073/pnas.1418084112. Epub 2015 Jan 26. PMID:25624472 doi:http://dx.doi.org/10.1073/pnas.1418084112
  3. ↑ Koc C, Gerlach D, Beck S, Peschel A, Xia G, Stehle T. Structural and enzymatic analysis of TarM from Staphylococcus aureus reveals an oligomeric protein specific for the glycosylation of wall teichoic acid. J Biol Chem. 2015 Feb 19. pii: jbc.M114.619924. PMID:25697358 doi:http://dx.doi.org/10.1074/jbc.M114.619924

4x7p, resolution 3.40Å

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