4or2: Difference between revisions

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 ==Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator==
-<StructureSection load='4or2' size='340' side='right' caption='[[4or2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+<StructureSection load='4or2' size='340' side='right'caption='[[4or2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4or2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OR2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4or2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OR2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OR2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=FM9:4-FLUORO-N-METHYL-N-{4-[6-(PROPAN-2-YLAMINO)PYRIMIDIN-4-YL]-1,3-THIAZOL-2-YL}BENZAMIDE'>FM9</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cybC, GRM1_HUMAN, GPRC1A, GRM1, MGLUR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=FM9:4-FLUORO-N-METHYL-N-{4-[6-(PROPAN-2-YLAMINO)PYRIMIDIN-4-YL]-1,3-THIAZOL-2-YL}BENZAMIDE'>FM9</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4or2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4or2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4or2 RCSB], [http://www.ebi.ac.uk/pdbsum/4or2 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4or2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4or2 OCA], [https://pdbe.org/4or2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4or2 RCSB], [https://www.ebi.ac.uk/pdbsum/4or2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4or2 ProSAT]</span></td></tr>
 </table>
+== Disease ==
+[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] Autosomal recessive congenital cerebellar ataxia due to MGLUR1 deficiency. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22901947</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX]] Electron-transport protein of unknown function.
+[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/GRM1_HUMAN GRM1_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.<ref>PMID:7476890</ref>
 ==See Also==
-*[[G protein-coupled receptor|G protein-coupled receptor]]
+*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]]
-*[[Metabotropic glutamate receptor|Metabotropic glutamate receptor]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Bacillus coli migula 1895]]
+[[Category: Escherichia coli]]
-[[Category: Cherezov, V]]
+[[Category: Homo sapiens]]
-[[Category: Cho, H P]]
+[[Category: Large Structures]]
-[[Category: Conn, P J]]
+[[Category: Cherezov V]]
-[[Category: GPCR, GPCR Network]]
+[[Category: Cho HP]]
-[[Category: Gregory, K J]]
+[[Category: Conn PJ]]
-[[Category: Han, G W]]
+[[Category: Gregory KJ]]
-[[Category: Katritch, V]]
+[[Category: Han GW]]
-[[Category: Niswender, C M]]
+[[Category: Katritch V]]
-[[Category: Stevens, R C]]
+[[Category: Niswender CM]]
-[[Category: Wang, C]]
+[[Category: Stevens RC]]
-[[Category: Wu, H]]
+[[Category: Wang C]]
-[[Category: Xia, Y]]
+[[Category: Wu H]]
-[[Category: Allosteric modulator]]
+[[Category: Xia Y]]
-[[Category: Gpcr]]
-[[Category: Gpcr network]]
-[[Category: Human metabotropic glutamate receptor 1]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Novel protein engineering]]
-[[Category: Psi-biology]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]