2ykt: Difference between revisions

 

==Crystal structure of the I-BAR domain of IRSp53 (BAIAP2) in complex with an EHEC derived Tir peptide==

<StructureSection load='2ykt' size='340' side='right'caption='[[2ykt]], [[Resolution|resolution]] 2.11&Aring;' scene=''>

<table><tr><td colspan='2'>[[2ykt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7_str._TW14359 Escherichia coli O157:H7 str. TW14359] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YKT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ykt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ykt OCA], [https://pdbe.org/2ykt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ykt RCSB], [https://www.ebi.ac.uk/pdbsum/2ykt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ykt ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BAIP2_HUMAN BAIP2_HUMAN] Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.<ref>PMID:11130076</ref> <ref>PMID:11696321</ref> <ref>PMID:14752106</ref> <ref>PMID:19366662</ref>  

[[Category: Large Structures]]

[[Category: Buessow K]]

[[Category: Carius Y]]

[[Category: Faix J]]

[[Category: Heinz DW]]

[[Category: Leong JM]]

[[Category: Lesser CF]]

[[Category: Quedenau C]]

[[Category: Reichelt J]]

[[Category: Schlueter K]]

[[Category: Standfuss-Gabisch C]]

[[Category: Stradal TEB]]

[[Category: Vingadassalom D]]

[[Category: Weiss SM]]

[[Category: De Groot JC]]