1uf7: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
(11 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1uf7.gif|left|200px]]


{{Structure
==Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valine==
|PDB= 1uf7 |SIZE=350|CAPTION= <scene name='initialview01'>1uf7</scene>, resolution 1.90&Aring;
<StructureSection load='1uf7' size='340' side='right'caption='[[1uf7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CDV:3-METHYL-2-UREIDO-BUTYRIC ACID'>CDV</scene>
<table><tr><td colspan='2'>[[1uf7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UF7 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/N-carbamoyl-D-amino_acid_hydrolase N-carbamoyl-D-amino acid hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.77 3.5.1.77]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDV:3-METHYL-2-UREIDO-BUTYRIC+ACID'>CDV</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uf7 OCA], [https://pdbe.org/1uf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1uf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uf7 ProSAT]</span></td></tr>
 
</table>
'''Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valine'''
== Function ==
 
[https://www.uniprot.org/uniprot/DCAS_AGRSK DCAS_AGRSK] The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1UF7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Agrobacterium_sp. Agrobacterium sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UF7 OCA].  
Check<jmol>
[[Category: Agrobacterium sp.]]
  <jmolCheckbox>
[[Category: N-carbamoyl-D-amino acid hydrolase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uf/1uf7_consurf.spt"</scriptWhenChecked>
[[Category: Single protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Aoki, M.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Hashimoto, H.]]
  </jmolCheckbox>
[[Category: Ikenaka, Y.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uf7 ConSurf].
[[Category: Morikawa, H.]]
<div style="clear:both"></div>
[[Category: Nakai, T.]]
__TOC__
[[Category: Sato, M.]]
</StructureSection>
[[Category: Shimizu, T.]]
[[Category: Agrobacterium sp]]
[[Category: Takahashi, S.]]
[[Category: Large Structures]]
[[Category: CDV]]
[[Category: Aoki M]]
[[Category: d-amino acid]]
[[Category: Hashimoto H]]
[[Category: hydrolase]]
[[Category: Ikenaka Y]]
[[Category: n-carbamyl-d-amino acid amidohydrolase]]
[[Category: Morikawa H]]
[[Category: n-carbamyl-d-valine]]
[[Category: Nakai T]]
 
[[Category: Sato M]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:31:17 2008''
[[Category: Shimizu T]]
[[Category: Takahashi S]]

Latest revision as of 02:52, 28 December 2023

Crystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valineCrystal structure of C171A/V236A Mutant of N-carbamyl-D-amino acid amidohydrolase complexed with N-carbamyl-D-valine

Structural highlights

1uf7 is a 2 chain structure with sequence from Agrobacterium sp.. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCAS_AGRSK The enzyme catalyzes the hydrolysis of N-carbamoyl-D-amino acids to the corresponding which are useful intermediates in the preparation of beta-lactam antibiotics. Industrial production of beta-lactam antibiotics is now being developed using this enzyme.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1uf7, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1uf7&oldid=4006894"