3zgi: Difference between revisions
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==Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP== | ==Crystal structure of the KRT10-binding region domain of the pneumococcal serine rich repeat protein PsrP== | ||
<StructureSection load='3zgi' size='340' side='right' caption='[[3zgi]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='3zgi' size='340' side='right'caption='[[3zgi]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zgi]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3zgi]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZGI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zgi OCA], [https://pdbe.org/3zgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zgi RCSB], [https://www.ebi.ac.uk/pdbsum/3zgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zgi ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PSRP_STRPN PSRP_STRPN] Protein that allows bacteria to adhere to mammalian host cells. Required for full virulence in mouse infection models when infected intranasally (PubMed:16861665). Required for adhesion to host cells in vitro and for persistence in the lower respiratory tract (PubMed:18507531). Binds host keratin 10 (KRT10) on lung cells which mediates adhesion via the C-terminus of the basic region (BR, residues 273-341); glycosylation of either protein is not required for the interaction (PubMed:19627498). A region in the N-terminus (residues 122-166) self aggregates, contributing to mature biofilm formation (PubMed:20714350). The basic region (BR, residues 187-385) also self aggregates; the BR binds DNA which enhances self aggregation (PubMed:27582320).<ref>PMID:16861665</ref> <ref>PMID:18507531</ref> <ref>PMID:19627498</ref> <ref>PMID:20714350</ref> <ref>PMID:27582320</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3zgi" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Achour | [[Category: Streptococcus pneumoniae TIGR4]] | ||
[[Category: Diamante | [[Category: Achour A]] | ||
[[Category: Ebel | [[Category: Diamante A]] | ||
[[Category: Henriques-Normark | [[Category: Ebel C]] | ||
[[Category: Hentrich | [[Category: Henriques-Normark B]] | ||
[[Category: Kikhney | [[Category: Hentrich K]] | ||
[[Category: Loefling | [[Category: Kikhney A]] | ||
[[Category: Mikaelsson | [[Category: Loefling J]] | ||
[[Category: Normark | [[Category: Mikaelsson C]] | ||
[[Category: Schulte | [[Category: Normark S]] | ||
[[Category: Svergun | [[Category: Schulte T]] | ||
[[Category: Svergun D]] | |||