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[[Image:1sow.gif|left|200px]]


{{Structure
==T. gondii bradyzoite-specific LDH (LDH2) in complex with NAD and oxalate==
|PDB= 1sow |SIZE=350|CAPTION= <scene name='initialview01'>1sow</scene>, resolution 1.9&Aring;
<StructureSection load='1sow' size='340' side='right'caption='[[1sow]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene> and <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
<table><tr><td colspan='2'>[[1sow]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SOW FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sow OCA], [https://pdbe.org/1sow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sow RCSB], [https://www.ebi.ac.uk/pdbsum/1sow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sow ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LDH_TOXGO LDH_TOXGO]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/so/1sow_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sow ConSurf].
<div style="clear:both"></div>


'''T. gondii bradyzoite-specific LDH (LDH2) in complex with NAD and oxalate'''
==See Also==
 
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1SOW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOW OCA].
[[Category: Large Structures]]
[[Category: L-lactate dehydrogenase]]
[[Category: Single protein]]
[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
[[Category: Kavanagh, K L.]]
[[Category: Kavanagh KL]]
[[Category: Wilson, D K.]]
[[Category: Wilson DK]]
[[Category: NAD]]
[[Category: OXL]]
[[Category: nad-binding]]
[[Category: rossmann fold]]
[[Category: tetramer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:46 2008''

Latest revision as of 09:19, 23 August 2023

T. gondii bradyzoite-specific LDH (LDH2) in complex with NAD and oxalateT. gondii bradyzoite-specific LDH (LDH2) in complex with NAD and oxalate

Structural highlights

1sow is a 2 chain structure with sequence from Toxoplasma gondii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LDH_TOXGO

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1sow, resolution 1.90Å

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