4ihf: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production==
-<StructureSection load='4ihf' size='340' side='right' caption='[[4ihf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='4ihf' size='340' side='right'caption='[[4ihf]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4ihf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoc1 Ecoc1] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IHF FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4ihf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Escherichia_coli_str._'clone_D_i14' Escherichia coli str. 'clone D i14']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IHF FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1F7:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+(3R)-3-HYDROXYTETRADECANETHIOATE'>1F7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ihg|4ihg]], [[4ihh|4ihh]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1F7:S-[2-({N-[(2S)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANYL}AMINO)ETHYL]+(3R)-3-HYDROXYTETRADECANETHIOATE'>1F7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lpxD, firA, omsA, b0179, JW0174 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), acpP, i14_1248 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=885275 ECOC1])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihf OCA], [https://pdbe.org/4ihf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ihf RCSB], [https://www.ebi.ac.uk/pdbsum/4ihf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ihf ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-3-O-(3-hydroxymyristoyl)glucosamine_N-acyltransferase UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.191 2.3.1.191] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ihf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ihf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ihf RCSB], [http://www.ebi.ac.uk/pdbsum/4ihf PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LPXD_ECOLI LPXD_ECOLI] Catalyzes the N-acylation of UDP-3-O-(hydroxymyristoyl)glucosamine using 3-hydroxymyristoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers R-3-hydroxymyristoyl-ACP over R-3-hydroxypalmitoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxymyristate at the 2 and 2' positions.<ref>PMID:8444173</ref> <ref>PMID:19655786</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4ihf" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Acyl carrier protein|Acyl carrier protein]]
+*[[Acyl carrier protein 3D structures|Acyl carrier protein 3D structures]]
+*[[UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase|UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Ecoc1]]
+[[Category: Escherichia coli K-12]]
-[[Category: Ecoli]]
+[[Category: Escherichia coli str. 'clone D i14']]
-[[Category: Masoudi, A]]
+[[Category: Large Structures]]
-[[Category: Pemble, C W]]
+[[Category: Masoudi A]]
-[[Category: Raetz, C R.H]]
+[[Category: Pemble CW]]
-[[Category: Acp mediated product release]]
+[[Category: Raetz CRH]]
-[[Category: Acp recognition domain]]
-[[Category: Acyl carrier protein]]
-[[Category: Acyltransferase]]
-[[Category: Left handed beta helix]]
-[[Category: Lipid some]]
-[[Category: Lpxd]]
-[[Category: Protein-protein complex]]
-[[Category: Transferase-lipid binding protein complex]]