3n0e: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==Crystal structure of WDR5 mutant (W330Y)==
-<StructureSection load='3n0e' size='340' side='right' caption='[[3n0e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='3n0e' size='340' side='right'caption='[[3n0e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3n0e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N0E FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3n0e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N0E FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mxx|3mxx]], [[3n0d|3n0d]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n0e RCSB], [http://www.ebi.ac.uk/pdbsum/3n0e PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0e OCA], [https://pdbe.org/3n0e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n0e RCSB], [https://www.ebi.ac.uk/pdbsum/3n0e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0e ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3n0e" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
 == References ==
 <references/>
@@ Line 19: / Line 26: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Chen, R C]]
+[[Category: Large Structures]]
-[[Category: Gao, Y]]
+[[Category: Chen R-C]]
-[[Category: Wu, X H]]
+[[Category: Gao Y]]
-[[Category: Wu, Y D]]
+[[Category: Wu X-H]]
-[[Category: Asp-his-ser-trp tetrad]]
+[[Category: Wu Y-D]]
-[[Category: Circular dichroism]]
-[[Category: Folding energy]]
-[[Category: Guanidine hydrochloride]]
-[[Category: Thermostability]]
-[[Category: Transcription]]
-[[Category: Wd-repeat protein 5]]
-[[Category: Wdr5]]