3k6y: Difference between revisions

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 ==Crystal structure of Rv3671c protease from M. tuberculosis, active form==
-<StructureSection load='3k6y' size='340' side='right' caption='[[3k6y]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
+<StructureSection load='3k6y' size='340' side='right'caption='[[3k6y]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3k6y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K6Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3k6y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6Y FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k6z|3k6z]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3772, Rv3671c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6y OCA], [https://pdbe.org/3k6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6y RCSB], [https://www.ebi.ac.uk/pdbsum/3k6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6y ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k6y RCSB], [http://www.ebi.ac.uk/pdbsum/3k6y PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/Y3671_MYCTU Y3671_MYCTU] Required for M.tuberculosis resistance to oxidative stress in addition to its role in resistance to acid, which is essential for virulence. It protects M.tuberculosis against phagolysosomal concentrations of acid and maintains its intrabacterial pH when phagocytosed by IFN-gamma-activated macrophages.<ref>PMID:18641659</ref> <ref>PMID:20947023</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3k6y" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Mycobacterium tuberculosis]]
-[[Category: Biswas, T]]
+[[Category: Biswas T]]
-[[Category: Ehrt, S]]
+[[Category: Ehrt S]]
-[[Category: Small, J]]
+[[Category: Small J]]
-[[Category: Tsodikov, O V]]
+[[Category: Tsodikov OV]]
-[[Category: Vandal, O]]
+[[Category: Vandal O]]
-[[Category: Bent helix]]
-[[Category: Disulfide]]
-[[Category: Hydrolase]]
-[[Category: Oxidative stress]]
-[[Category: Protease]]
-[[Category: Serine protease]]