1vtn: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 ==CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE H5==
-<StructureSection load='1vtn' size='340' side='right' caption='[[1vtn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='1vtn' size='340' side='right'caption='[[1vtn]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1vtn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VTN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1vtn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VTN FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vtn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vtn RCSB], [http://www.ebi.ac.uk/pdbsum/1vtn PDBsum]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vtn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vtn OCA], [https://pdbe.org/1vtn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vtn RCSB], [https://www.ebi.ac.uk/pdbsum/1vtn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vtn ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/FOXA3_HUMAN FOXA3_HUMAN] Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.<ref>PMID:12695546</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 1vtn" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
@@ Line 19: / Line 24: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Burley, S K]]
+[[Category: Large Structures]]
-[[Category: Clark, K L]]
+[[Category: Burley SK]]
-[[Category: Halay, E D]]
+[[Category: Clark KL]]
-[[Category: Lai, E]]
+[[Category: Halay ED]]
-[[Category: Double helix]]
+[[Category: Lai E]]
-[[Category: Protein-dna complex]]
-[[Category: Transcription-dna complex]]