4u4z: Difference between revisions

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 ==Crystal structure of Phyllanthoside bound to the yeast 80S ribosome==
-<StructureSection load='4u4z' size='340' side='right' caption='[[4u4z]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+<StructureSection load='4u4z' size='340' side='right'caption='[[4u4z]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4u4z]] is a 162 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_atcc_204508_/_s288c Saccharomyces cerevisiae atcc 204508 / s288c]. This structure supersedes the now removed PDB entries  and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ulo 4ulo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U4Z FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4u4z]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ulj 4ulj], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ulk 4ulk], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ulm 4ulm], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uln 4uln] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4ulo 4ulo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U4Z FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3K5:3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2S,3aR,4S,5R,6S,7aS)-5-methyl-4-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3-[1]benzofuran-2,2-pyran]-6-yl]carbonyl}-beta-D-glucopyranose'>3K5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3K5:3-O-acetyl-2-O-(3-O-acetyl-6-deoxy-beta-D-glucopyranosyl)-6-deoxy-1-O-{[(2R,2S,3aR,4S,5R,6S,7aS)-5-methyl-4-{[(2E)-3-phenylprop-2-enoyl]oxy}decahydrodispiro[oxirane-2,3-[1]benzofuran-2,2-pyran]-6-yl]carbonyl}-beta-D-glucopyranose'>3K5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OHX:OSMIUM+(III)+HEXAMMINE'>OHX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ulj|4ulj]], [[4ulk|4ulk]], [[4ulm|4ulm]], [[4uln|4uln]], [[4ulo|4ulo]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4z OCA], [https://pdbe.org/4u4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u4z RCSB], [https://www.ebi.ac.uk/pdbsum/4u4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u4z ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u4z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u4z RCSB], [http://www.ebi.ac.uk/pdbsum/4u4z PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/STM1_YEAST STM1_YEAST] Binds specifically G4 quadruplex (these are four-stranded right-handed helices, stabilized by guanine base quartets) and purine motif triplex (characterized by a third, antiparallel purine-rich DNA strand located within the major groove of a homopurine stretch of duplex DNA) nucleic acid structures. These structures may be present at telomeres or in rRNAs. Acts with CDC13 to control telomere length homeostasis. Involved in the control of the apoptosis-like cell death.<ref>PMID:15044472</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4u4z" style="background-color:#fffaf0;"></div>
 ==See Also==
 *[[Ribosome 3D structures|Ribosome 3D structures]]
+*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Saccharomyces cerevisiae atcc 204508 / s288c]]
+[[Category: Large Structures]]
-[[Category: Loubresse, N Garreau de]]
+[[Category: Saccharomyces cerevisiae S288C]]
-[[Category: Prokhorova, I]]
+[[Category: Garreau de Loubresse N]]
-[[Category: Yusupov, M]]
+[[Category: Prokhorova I]]
-[[Category: Yusupova, G]]
+[[Category: Yusupov M]]
-[[Category: Antibiotic]]
+[[Category: Yusupova G]]
-[[Category: Eukaryote]]
-[[Category: Inhibitor]]
-[[Category: Ribosome]]
-[[Category: Rna-protein complex]]
-[[Category: Translation]]