1onk: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1onk.gif|left|200px]]
- {{Structure
+==Mistletoe lectin I from viscum album==
-|PDB= 1onk |SIZE=350|CAPTION= <scene name='initialview01'>1onk</scene>, resolution 2.10&Aring;
+<StructureSection load='1onk' size='340' side='right'caption='[[1onk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
+<table><tr><td colspan='2'>[[1onk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ONK FirstGlance]. <br>
-|ACTIVITY= [http://en.wikipedia.org/wiki/rRNA_N-glycosylase rRNA N-glycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.22 3.2.2.22]
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-}}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1onk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1onk OCA], [https://pdbe.org/1onk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1onk RCSB], [https://www.ebi.ac.uk/pdbsum/1onk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1onk ProSAT]</span></td></tr>
+</table>
-'''Mistletoe lectin I from viscum album'''
+== Function ==
+[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-ONK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ONK OCA].
+Check<jmol>
-[[Category: Protein complex]]
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/on/1onk_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1onk ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Viscum album]]
-[[Category: rRNA N-glycosylase]]
+[[Category: Betzel C]]
-[[Category: Betzel, C.]]
+[[Category: Gabdoulkhakov AG]]
-[[Category: Gabdoulkhakov, A G.]]
+[[Category: Konareva N]]
-[[Category: Konareva, N.]]
+[[Category: Kornev AN]]
-[[Category: Kornev, A N.]]
+[[Category: Kornilov V]]
-[[Category: Kornilov, V.]]
+[[Category: Krauspenhaar R]]
-[[Category: Krauspenhaar, R.]]
+[[Category: Mikhailov AM]]
-[[Category: Mikhailov, A M.]]
+[[Category: Nikonov SV]]
-[[Category: Nikonov, S V.]]
+[[Category: Savoshkina Y]]
-[[Category: Savoshkina, Y.]]
+[[Category: Stoeva S]]
-[[Category: Stoeva, S.]]
+[[Category: Voelter W]]
-[[Category: Voelter, W.]]
-[[Category: AZI]]
-[[Category: GOL]]
-[[Category: NAG]]
-[[Category: PO4]]
-[[Category: ribosome-inactivating protein type ii]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:13:17 2008''