4baa: Difference between revisions

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 ==Redesign of a Phenylalanine Aminomutase into a beta-Phenylalanine Ammonia Lyase==
-<StructureSection load='4baa' size='340' side='right' caption='[[4baa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='4baa' size='340' side='right'caption='[[4baa]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4baa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Taxus_wallichiana_var._chinensis Taxus wallichiana var. chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BAA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4baa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Taxus_chinensis Taxus chinensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BAA FirstGlance]. <br>
-</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yii|2yii]], [[4bab|4bab]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_ammonia-lyase Phenylalanine ammonia-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.1.24 4.3.1.24] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4baa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4baa OCA], [https://pdbe.org/4baa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4baa RCSB], [https://www.ebi.ac.uk/pdbsum/4baa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4baa ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4baa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4baa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4baa RCSB], [http://www.ebi.ac.uk/pdbsum/4baa PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PAM_TAXCH PAM_TAXCH] Phenylalanine aminomutase that catalyzes the rearrangement of L-phenylalanine to R-beta-phenylalanine. Catalyzes the first committed step in the biosynthesis of the side chain of the alkaloid taxol (paclitaxel), a widely-used compound with antitumor activity. Has also low phenylalanine ammonia-lyase activity and can catalyze the amination of trans-cinnamate.<ref>PMID:15878763</ref> <ref>PMID:22113970</ref> <ref>PMID:24786474</ref>
+==See Also==
+*[[Aminomutase 3D structures|Aminomutase 3D structures]]
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Phenylalanine ammonia-lyase]]
+[[Category: Large Structures]]
-[[Category: Taxus wallichiana var. chinensis]]
+[[Category: Taxus chinensis]]
-[[Category: Bartsch, S]]
+[[Category: Bartsch S]]
-[[Category: Dijkstra, B W]]
+[[Category: Dijkstra BW]]
-[[Category: Heberling, M M]]
+[[Category: Heberling MM]]
-[[Category: Jansen, M]]
+[[Category: Jansen M]]
-[[Category: Janssen, D B]]
+[[Category: Janssen DB]]
-[[Category: Wu, B]]
+[[Category: Wu B]]
-[[Category: Wybenga, G G]]
+[[Category: Wybenga GG]]
-[[Category: Lyase]]
-[[Category: Mio]]