3qnf: Difference between revisions
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==Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1== | ==Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1== | ||
<StructureSection load='3qnf' size='340' side='right' caption='[[3qnf]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='3qnf' size='340' side='right'caption='[[3qnf]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3qnf]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3qnf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QNF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qnf OCA], [https://pdbe.org/3qnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qnf RCSB], [https://www.ebi.ac.uk/pdbsum/3qnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qnf ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ERAP1_HUMAN ERAP1_HUMAN] Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.<ref>PMID:15908954</ref> <ref>PMID:16286653</ref> <ref>PMID:21478864</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3qnf" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Aminopeptidase|Aminopeptidase]] | *[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Allerston | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Allerston C]] | ||
[[Category: Berridge | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Berridge G]] | ||
[[Category: Chaikuad | [[Category: Bountra C]] | ||
[[Category: Chaikuad A]] | |||
[[Category: Edwards | [[Category: Edwards A]] | ||
[[Category: Harvey | [[Category: Harvey D]] | ||
[[Category: Kavanagh | [[Category: Kavanagh K]] | ||
[[Category: Kochan | [[Category: Kochan G]] | ||
[[Category: Krojer | [[Category: Krojer T]] | ||
[[Category: Muniz | [[Category: Muniz JRC]] | ||
[[Category: Oppermann | [[Category: Oppermann U]] | ||
[[Category: Raynor | [[Category: Raynor J]] | ||
[[Category: Ugochukwu E]] | |||
[[Category: Ugochukwu | [[Category: Vollmar M]] | ||
[[Category: Vollmar | [[Category: Wordsworth BP]] | ||
[[Category: Wordsworth | [[Category: Von Delft F]] | ||
[[Category: | |||