3ldq: Difference between revisions
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==Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor== | ==Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor== | ||
<StructureSection load='3ldq' size='340' side='right' caption='[[3ldq]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3ldq' size='340' side='right'caption='[[3ldq]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ldq]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ldq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDQ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3P1:8-[(QUINOLIN-2-YLMETHYL)AMINO]ADENOSINE'>3P1</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldq OCA], [https://pdbe.org/3ldq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldq RCSB], [https://www.ebi.ac.uk/pdbsum/3ldq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldq ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HSP7C_HUMAN HSP7C_HUMAN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex.<ref>PMID:10722728</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3ldq" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[BAG | *[[BAG family proteins 3D structures|BAG family proteins 3D structures]] | ||
*[[Heat Shock | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Dokurno | [[Category: Large Structures]] | ||
[[Category: Macias | [[Category: Dokurno P]] | ||
[[Category: Massey | [[Category: Macias AT]] | ||
[[Category: Shaw | [[Category: Massey AJ]] | ||
[[Category: Surgenor | [[Category: Shaw T]] | ||
[[Category: Williamson | [[Category: Surgenor AE]] | ||
[[Category: Williamson DS]] | |||