Eric Comeau/ sandbox: Difference between revisions
Eric Comeau (talk | contribs) No edit summary |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
== | == Physical model == | ||
The 3D-printed models are of the tetramer, with one beta subunit valine marked with a blue rod. One hydrophobic surface patch is marked with a hole. In the browser, the <scene name='61/611454/One_with_val/1'>tetramer</scene> is shown in red (alpha subunits) and orangered (beta subunits), with both valines shown in blue. In a second scene, <scene name='61/611454/Two_with_val/1'>two interacting tetramers</scene> are shown. You can see that one of the four valines is buried in the contact area between the two tetramers. The <scene name='61/611454/Val_and_patch/2'>hydrophobic patch</scene> (shown in gray) consists of Phe 85 and Leu 88 side chains in an indentation of the protein's surface. | |||
== Sickle Cell Anemia == | == Sickle Cell Anemia == | ||
<scene name='61/611454/Hemoglobin/7'>Two hemoglobin proteins with mutated Beta protein</scene> | <scene name='61/611454/Hemoglobin/7'>Two hemoglobin proteins with mutated Beta protein</scene> | ||
The <scene name='61/611454/Hemoglobin/9'>hydrophobic patch</scene> is shown in gray, the mutations to valine in blue. | |||
<scene name='61/611454/Hemoglobin/8'>Hemoglobin and Valine</scene> | <scene name='61/611454/Hemoglobin/8'>Hemoglobin and Valine</scene> | ||