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Insulin-like growth factor receptor: Difference between revisions

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<StructureSection load='' size='450' side='right' scene='Journal:JBSD:38/Cv/1' caption='Human insulin-like growth factor 1 receptor (PDB code [[3i81]])'>   
<StructureSection load='3i81' size='350' side='right' scene='' caption='Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code [[3i81]])'>   
'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF).  IGFR contains 2 extracellular α chains and 2 transmembranal β chains.  Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling.
'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF).  IGFR contains 2 extracellular α chains and 2 transmembranal β chains.  Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]].
 
*'''Insulin-like growth factor receptor 1''' is the mediator of the anabolic and mitogenic activity of growth hormone<ref>PMID: 11577173</ref><br />
*'''Insulin-like growth factor receptor 2''' is a protein hormone regulating cell proliferation, growth, migration, differentiation and survival<ref>PMID: 23257688</ref><br />.


===  Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===
===  Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===
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*IGFR I
*IGFR I


**[[1igr]] – hIGFR I domains 1-3 – human<BR />
**[[1igr]] – hIGFR I domains 1-3 31-492– human<BR />
**[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) <BR />
**[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) 983-1286<BR />
**[[1m7n]] - hIGFR I kinase domain<BR />
**[[1m7n]] - hIGFR I kinase domain<BR />
**[[1k3a]] -  hIGFR I kinase domain + insulin receptor substrate peptide<BR />
**[[1k3a]] -  hIGFR I kinase domain + insulin receptor substrate peptide<BR />
**[[2oj9]], [[2zm3]], [[3d94]], [[3f5p]], [[3i81]], [[3lvp]], [[3nw5]], [[3nw6]], [[3nw7]], [[3lw0]], [[3qqu]], [[3o23]] - hIGFR I kinase domain + inhibitor<BR />
**[[2oj9]], [[2zm3]], [[3d94]], [[3f5p]], [[3i81]], [[3lvp]], [[3nw5]], [[3nw6]], [[3nw7]], [[3lw0]], [[3qqu]], [[3o23]], [[4d2r]], [[5fxq]], [[5fxr]], [[5fxs]], [[5hzn]] - hIGFR I kinase domain + inhibitor<BR />
**[[5u8r]] - hIGFR I (mutant) + antibody<BR />
**[[5u8q]] - hIGFR I (mutant) + IGFI + antibody<BR />
**[[6pyh]] - hIGFR I + IGFI – Cryo EM<BR />
**[[6vwg]], [[6vwh]], [[6vwi]], [[6vwj]] - hIGFR I + IGFII – Cryo EM<BR />
**[[7s8v]] - hIGFR I + insulin receptor – Cryo EM<BR />
**[[7s0q]] - hIGFR I + insulin receptor + IGF I – Cryo EM<BR />


*IGFR II
*IGFR II
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**[[2kva]] - hIGFR II domain 5 – NMR<BR />
**[[2kva]] - hIGFR II domain 5 – NMR<BR />
**[[2cnj]] - hIGFR II domain 11 - NMR<BR />
**[[2cnj]] - hIGFR II domain 11 - NMR<BR />
**[[2l2a]] - hIGFR II domains 11 (mutant) - NMR<BR />
**[[2l2a]], [[2m68]], [[2m6t]] - hIGFR II domains 11 (mutant) - NMR<BR />
**[[2kvb]] - hIGFR II domain 5 + inhibitor – NMR<BR />
**[[2kvb]] - hIGFR II domain 5 + inhibitor – NMR<BR />
**[[2v5n]] - hIGFR II domains 11-12<BR />
**[[2v5n]] - hIGFR II domains 11-12<BR />
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**[[1syo]], [[1sz0]] - bIGFR II domains 1-3 + mannose-6-phosphate<BR />
**[[1syo]], [[1sz0]] - bIGFR II domains 1-3 + mannose-6-phosphate<BR />
**[[2lla]] - IGFR II domain 11 – short-beaked echidna - NMR<BR />
**[[2lla]] - IGFR II domain 11 – short-beaked echidna - NMR<BR />
**[[2l2g]] - IGFR II domain 11 – opossum - NMR<BR />
}}
}}
== References ==
== References ==

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
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