2mwn: Difference between revisions
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The | ==Talin-F3 / RIAM N-terminal Peptide complex== | ||
<StructureSection load='2mwn' size='340' side='right'caption='[[2mwn]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mwn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MWN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mwn OCA], [https://pdbe.org/2mwn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mwn RCSB], [https://www.ebi.ac.uk/pdbsum/2mwn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mwn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AB1IP_HUMAN AB1IP_HUMAN] Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.<ref>PMID:14530287</ref> <ref>PMID:15469846</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The membrane localization and activation of cytoskeletal protein talin are key steps to initiate the integrin transmembrane receptors' activation, which mediates many cellular adhesive responses such as cell migration, spreading and proliferation. RIAM, a membrane anchor and small GTPase RAP1 effector, is known to bind to the C-terminal rod domain of talin (talin-R) and promote localizations of talin to the membrane. Through systematic mapping analysis, we find that RIAM also binds to the N-terminal head of talin (talin-H), a crucial domain involved in binding and activating integrins. We show that the RIAM binding to talin-H sterically occludes the binding of a talin-R domain that otherwise masks the integrin-binding site on talin-H. We further provide functional evidence that such RIAM-mediated steric unmasking of talin triggers integrin activation. Our findings thus uncover a novel role for RIAM in conformational regulation of talin during integrin activation and cell adhesion. | |||
Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.,Yang J, Zhu L, Zhang H, Hirbawi J, Fukuda K, Dwivedi P, Liu J, Byzova T, Plow EF, Wu J, Qin J Nat Commun. 2014 Dec 18;5:5880. doi: 10.1038/ncomms6880. PMID:25520155<ref>PMID:25520155</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mwn" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Talin 3D structures|Talin 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Byzova T]] | |||
[[Category: Dwivedi P]] | |||
[[Category: Fukuda K]] | |||
[[Category: Hirbawi J]] | |||
[[Category: Liu J]] | |||
[[Category: Plow EF]] | |||
[[Category: Qin J]] | |||
[[Category: Wu J]] | |||
[[Category: Yang J]] | |||
[[Category: Zhang H]] | |||
[[Category: Zhu L]] | |||
Latest revision as of 09:11, 15 May 2024
Talin-F3 / RIAM N-terminal Peptide complexTalin-F3 / RIAM N-terminal Peptide complex
Structural highlights
FunctionAB1IP_HUMAN Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.[1] [2] Publication Abstract from PubMedThe membrane localization and activation of cytoskeletal protein talin are key steps to initiate the integrin transmembrane receptors' activation, which mediates many cellular adhesive responses such as cell migration, spreading and proliferation. RIAM, a membrane anchor and small GTPase RAP1 effector, is known to bind to the C-terminal rod domain of talin (talin-R) and promote localizations of talin to the membrane. Through systematic mapping analysis, we find that RIAM also binds to the N-terminal head of talin (talin-H), a crucial domain involved in binding and activating integrins. We show that the RIAM binding to talin-H sterically occludes the binding of a talin-R domain that otherwise masks the integrin-binding site on talin-H. We further provide functional evidence that such RIAM-mediated steric unmasking of talin triggers integrin activation. Our findings thus uncover a novel role for RIAM in conformational regulation of talin during integrin activation and cell adhesion. Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion.,Yang J, Zhu L, Zhang H, Hirbawi J, Fukuda K, Dwivedi P, Liu J, Byzova T, Plow EF, Wu J, Qin J Nat Commun. 2014 Dec 18;5:5880. doi: 10.1038/ncomms6880. PMID:25520155[3] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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