3d48: Difference between revisions

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 ==Crystal structure of a prolactin receptor antagonist bound to the extracellular domain of the prolactin receptor==
-<StructureSection load='3d48' size='340' side='right' caption='[[3d48]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='3d48' size='340' side='right'caption='[[3d48]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3d48]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3D48 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3d48]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3D48 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bp3|1bp3]], [[1f6f|1f6f]], [[1rw5|1rw5]], [[1n9d|1n9d]], [[2q98|2q98]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PRLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3d48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d48 OCA], [https://pdbe.org/3d48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3d48 RCSB], [https://www.ebi.ac.uk/pdbsum/3d48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3d48 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3d48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3d48 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3d48 RCSB], [http://www.ebi.ac.uk/pdbsum/3d48 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRL_HUMAN PRL_HUMAN] Prolactin acts primarily on the mammary gland by promoting lactation.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/3d48_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d4/3d48_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3d48 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3d48" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Prolactin|Prolactin]]
+*[[Prolactin receptor|Prolactin receptor]]
 == References ==
 <references/>
@@ Line 31: / Line 38: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Breinholt, J]]
+[[Category: Large Structures]]
-[[Category: Svensson, L A]]
+[[Category: Breinholt J]]
-[[Category: Cytokine-cytokine receptor complex]]
+[[Category: Svensson LA]]
-[[Category: Four-helix bundle]]
-[[Category: Glycoprotein]]
-[[Category: Hormone]]
-[[Category: Hormone-hormone receptor complex]]
-[[Category: Lactation]]
-[[Category: Membrane]]
-[[Category: Receptor]]
-[[Category: Secreted]]
-[[Category: Transmembrane]]