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| ==Crystal structure analysis of cruzain bound to covalent reversible analog of WRR-483 (WRR-669)==
| | #REDIRECT [[4xui]] This PDB entry is obsolete and replaced by 4xui |
| <StructureSection load='4pi4' size='340' side='right' caption='[[4pi4]], [[Resolution|resolution]] 2.51Å' scene=''>
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| == Structural highlights ==
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| <table><tr><td colspan='2'>[[4pi4]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PI4 FirstGlance]. <br>
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| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VC:N-[(2S)-5-(CARBAMIMIDAMIDOOXY)-1-OXO-1-{[(1E,3S)-5-PHENYL-1-(PYRIMIDIN-2-YLSULFONYL)PENT-1-EN-3-YL]AMINO}PENTAN-2-YL]-4-METHYLPIPERAZINE-1-CARBOXAMIDE'>2VC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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| <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lxs|3lxs]], [[2oz2|2oz2]], [[4pi3|4pi3]]</td></tr>
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| <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pi4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pi4 RCSB], [http://www.ebi.ac.uk/pdbsum/4pi4 PDBsum]</span></td></tr>
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| </table>
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| __TOC__
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| </StructureSection>
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| [[Category: Cruzipain]]
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| [[Category: McKerrow, J H]]
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| [[Category: Tochowicz, A]]
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| [[Category: Chagas disease]]
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| [[Category: Covalent reversible inhibitor]]
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| [[Category: Cruzain]]
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| [[Category: Cysteine protease]]
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| [[Category: Hydrolase-hydrolase inhibitor complex]]
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| [[Category: Trypanosoma cruzi]]
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| [[Category: Vinyl sulfone analog]]
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This PDB entry is obsolete and replaced by 4xui