2xs1: Difference between revisions

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-==CRYSTAL STRUCTURE OF ALIX IN COMPLEX WITH THE SIVMAC239 PYKEVTEDL LATE DOMAIN==
-<StructureSection load='2xs1' size='340' side='right' caption='[[2xs1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+==Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain==
+<StructureSection load='2xs1' size='340' side='right'caption='[[2xs1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2xs1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XS1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2xs1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Simian_immunodeficiency_virus Simian immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XS1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XS1 FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xs8|2xs8]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.296&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xs1 RCSB], [http://www.ebi.ac.uk/pdbsum/2xs1 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xs1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xs1 OCA], [https://pdbe.org/2xs1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xs1 RCSB], [https://www.ebi.ac.uk/pdbsum/2xs1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xs1 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDC6I_HUMAN PDC6I_HUMAN] Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.<ref>PMID:14505569</ref> <ref>PMID:14505570</ref> <ref>PMID:14739459</ref> <ref>PMID:17853893</ref> <ref>PMID:17428861</ref> <ref>PMID:17556548</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2xs1" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[Gag polyprotein|Gag polyprotein]]
 == References ==
 <references/>
@@ Line 22: / Line 23: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Hill, C P.]]
+[[Category: Large Structures]]
-[[Category: Landesman, M.]]
+[[Category: Simian immunodeficiency virus]]
-[[Category: Robinson, H.]]
+[[Category: Hill CP]]
-[[Category: Sundquist, W I.]]
+[[Category: Landesman M]]
-[[Category: Zhai, Q.]]
+[[Category: Robinson H]]
-[[Category: Cell cycle]]
+[[Category: Sundquist WI]]
-[[Category: Protein transport-viral protein complex]]
+[[Category: Zhai Q]]