4mq4: Difference between revisions

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 ==Crystal Structure of hPNMT in Complex with bisubstrate inhibitor N-(3-((((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)propyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide==
-<StructureSection load='4mq4' size='340' side='right' caption='[[4mq4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+<StructureSection load='4mq4' size='340' side='right'caption='[[4mq4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4mq4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MQ4 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4mq4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MQ4 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2D5:5-S-(3-{[(3R)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YLCARBONYL]AMINO}PROPYL)-5-THIOADENOSINE'>2D5</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2042&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hnn|1hnn]], [[2g72|2g72]], [[4mik|4mik]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2D5:5-S-(3-{[(3R)-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YLCARBONYL]AMINO}PROPYL)-5-THIOADENOSINE'>2D5</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mq4 OCA], [https://pdbe.org/4mq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mq4 RCSB], [https://www.ebi.ac.uk/pdbsum/4mq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mq4 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mq4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mq4 RCSB], [http://www.ebi.ac.uk/pdbsum/4mq4 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
+==See Also==
+*[[Phenylethanolamine N-methyltransferase|Phenylethanolamine N-methyltransferase]]
 __TOC__
 </StructureSection>
-[[Category: Phenylethanolamine N-methyltransferase]]
+[[Category: Homo sapiens]]
-[[Category: Bart, A G.]]
+[[Category: Large Structures]]
-[[Category: Scott, E E.]]
+[[Category: Bart AG]]
-[[Category: Adrenaline synthesis]]
+[[Category: Scott EE]]
-[[Category: Methyltransferase]]
-[[Category: Transferase-transferase inhibitor complex]]