1jce: Difference between revisions

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[[Image:1jce.gif|left|200px]]


{{Structure
==MREB FROM THERMOTOGA MARITIMA==
|PDB= 1jce |SIZE=350|CAPTION= <scene name='initialview01'>1jce</scene>, resolution 2.1&Aring;
<StructureSection load='1jce' size='340' side='right'caption='[[1jce]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND=
<table><tr><td colspan='2'>[[1jce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JCE FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= TM0588 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jce OCA], [https://pdbe.org/1jce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jce RCSB], [https://www.ebi.ac.uk/pdbsum/1jce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jce ProSAT]</span></td></tr>
 
</table>
'''MREB FROM THERMOTOGA MARITIMA'''
== Function ==
 
[https://www.uniprot.org/uniprot/Q9WZ57_THEMA Q9WZ57_THEMA]
 
== Evolutionary Conservation ==
==Overview==
[[Image:Consurf_key_small.gif|200px|right]]
It was thought until recently that bacteria lack the actin or tubulin filament networks that organize eukaryotic cytoplasm. However, we show here that the bacterial MreB protein assembles into filaments with a subunit repeat similar to that of F-actin-the physiological polymer of eukaryotic actin. By elucidating the MreB crystal structure we demonstrate that MreB and actin are very similar in three dimensions. Moreover, the crystals contain protofilaments, allowing visualization of actin-like strands at atomic resolution. The structure of the MreB protofilament is in remarkably good agreement with the model for F-actin, showing that the proteins assemble in identical orientations. The actin-like properties of MreB explain the finding that MreB forms large fibrous spirals under the cell membrane of rod-shaped cells, where they are involved in cell-shape determination. Thus, prokaryotes are now known to possess homologues both of tubulin, namely FtsZ, and of actin.
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/1jce_consurf.spt"</scriptWhenChecked>
1JCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JCE OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==Reference==
  </jmolCheckbox>
Prokaryotic origin of the actin cytoskeleton., van den Ent F, Amos LA, Lowe J, Nature. 2001 Sep 6;413(6851):39-44. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11544518 11544518]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jce ConSurf].
[[Category: Single protein]]
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Amos, L A.]]
[[Category: Amos LA]]
[[Category: Ent, F van den.]]
[[Category: Lowe J]]
[[Category: Lowe, J.]]
[[Category: Van den Ent F]]
[[Category: actin]]
[[Category: ftsz]]
[[Category: hsp-70]]
[[Category: mbl]]
[[Category: mreb]]
[[Category: rod-shape determining]]
 
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