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[[Image:1j2g.gif|left|200px]]


{{Structure
==Crystal structure of Urate oxidase from Bacillus SP. TB-90 co-crystallized with 8-Azaxanthine==
|PDB= 1j2g |SIZE=350|CAPTION= <scene name='initialview01'>1j2g</scene>, resolution 2.20&Aring;
<StructureSection load='1j2g' size='340' side='right'caption='[[1j2g]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>
<table><tr><td colspan='2'>[[1j2g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._TB-90 Bacillus sp. TB-90]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J2G FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Urate_oxidase Urate oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.7.3.3 1.7.3.3]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZA:8-AZAXANTHINE'>AZA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j2g OCA], [https://pdbe.org/1j2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j2g RCSB], [https://www.ebi.ac.uk/pdbsum/1j2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j2g ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PUCL_BACSB PUCL_BACSB] Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j2/1j2g_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j2g ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Urate oxidase from Bacillus SP. TB-90 co-crystallized with 8-Azaxanthine'''
==See Also==
 
*[[Urate oxidase 3D structures|Urate oxidase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1J2G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_sp. Bacillus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J2G OCA].
[[Category: Bacillus sp. TB-90]]
[[Category: Bacillus sp.]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Hibi T]]
[[Category: Urate oxidase]]
[[Category: Nago T]]
[[Category: Hibi, T.]]
[[Category: Nishiya Y]]
[[Category: Nago, T.]]
[[Category: Oda J]]
[[Category: Nishiya, Y.]]
[[Category: Oda, J.]]
[[Category: AZA]]
[[Category: SO4]]
[[Category: purine]]
[[Category: t-fold barrel]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:58:04 2008''

Latest revision as of 02:41, 28 December 2023

Crystal structure of Urate oxidase from Bacillus SP. TB-90 co-crystallized with 8-AzaxanthineCrystal structure of Urate oxidase from Bacillus SP. TB-90 co-crystallized with 8-Azaxanthine

Structural highlights

1j2g is a 4 chain structure with sequence from Bacillus sp. TB-90. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PUCL_BACSB Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1j2g, resolution 2.20Å

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