2wo5: Difference between revisions

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-==STRUCTURE OF WILD TYPE E. COLI N-ACETYLNEURAMINIC ACID LYASE IN SPACE GROUP P21 CRYSTAL FORM I==
-<StructureSection load='2wo5' size='340' side='right' caption='[[2wo5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+==Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form I==
+<StructureSection load='2wo5' size='340' side='right'caption='[[2wo5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wo5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WO5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wo5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WO5 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wnq|2wnq]], [[2wkj|2wkj]], [[1fdz|1fdz]], [[1fdy|1fdy]], [[2wsg|2wsg]], [[2wpb|2wpb]], [[1nal|1nal]], [[2wnn|2wnn]], [[1hl2|1hl2]], [[2wnz|2wnz]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylneuraminate_lyase N-acetylneuraminate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.3 4.1.3.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo5 OCA], [https://pdbe.org/2wo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wo5 RCSB], [https://www.ebi.ac.uk/pdbsum/2wo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo5 ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wo5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wo5 PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/NANA_ECOLI NANA_ECOLI] Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate.[HAMAP-Rule:MF_01237]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wo5_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wo5_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wo5 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 25: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2wo5" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Aldolase|Aldolase]]
+*[[N-acetylneuraminate lyase 3D structures|N-acetylneuraminate lyase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Escherichia coli]]
+[[Category: Large Structures]]
-[[Category: N-acetylneuraminate lyase]]
+[[Category: Berry A]]
-[[Category: Berry, A.]]
+[[Category: Bolt AH]]
-[[Category: Bolt, A H.]]
+[[Category: Campeotto I]]
-[[Category: Campeotto, I.]]
+[[Category: Dennis CA]]
-[[Category: Dennis, C A.]]
+[[Category: Harman TA]]
-[[Category: Harman, T A.]]
+[[Category: Nelson A]]
-[[Category: Nelson, A.]]
+[[Category: Pearson AR]]
-[[Category: Pearson, A R.]]
+[[Category: Phillips SEV]]
-[[Category: Phillips, S E.V.]]
+[[Category: Trinh CH]]
-[[Category: Trinh, C H.]]
-[[Category: Aldolase]]
-[[Category: Carbohydrate metabolism]]
-[[Category: Directed evolution]]
-[[Category: Lyase]]
-[[Category: Protein engineering]]
-[[Category: Schiff base]]
-[[Category: Substrate specificity]]