4rdn: Difference between revisions

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-'''Unreleased structure'''
-The entry 4rdn is ON HOLD
+==Structure of YTH-YTHDF2 in complex with m6A==
+<StructureSection load='4rdn' size='340' side='right'caption='[[4rdn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Li, F.D., Zhao, D.B., Wu, J.H., Shi, Y.Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rdn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RDN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RDN FirstGlance]. <br>
-Description: Structure of YTH-YTHDF2 in complex with m6A
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6MD:N-METHYLADENOSINE'>6MD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rdn OCA], [https://pdbe.org/4rdn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rdn RCSB], [https://www.ebi.ac.uk/pdbsum/4rdn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rdn ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/YTHD2_HUMAN YTHD2_HUMAN] Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.<ref>PMID:22575960</ref> <ref>PMID:24284625</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li FD]]
+[[Category: Shi YY]]
+[[Category: Wu JH]]
+[[Category: Zhao DB]]