2p4l: Difference between revisions
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==Structure and sodium channel activity of an excitatory I1-superfamily conotoxin== | ==Structure and sodium channel activity of an excitatory I1-superfamily conotoxin== | ||
<StructureSection load='2p4l' size='340' side='right' caption='[[2p4l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | <StructureSection load='2p4l' size='340' side='right'caption='[[2p4l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p4l]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2p4l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conra Conra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P4L FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4l OCA], [https://pdbe.org/2p4l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p4l RCSB], [https://www.ebi.ac.uk/pdbsum/2p4l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4l ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/CI1BA_CONRA CI1BA_CONRA]] Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin acts on Nav1.6/SCN8A > Nav1.2/SCN2A > Nav1.7/SCN9A sodium channels. Produces general excitatory symptoms upon intracorporeal injection and repetitive action potentials in the frog cutaneous pectoris muscle. Natural peptide (with D-Phe) is active on nerve, but not on muscle. Synthetic peptide (with L-Phe) is not active on both nerve and muscle.<ref>PMID:17696362</ref> <ref>PMID:18486102</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/2p4l_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/2p4l_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p4l ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2p4l" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Conra]] | ||
[[Category: Babon, J J | [[Category: Large Structures]] | ||
[[Category: Buczek, O | [[Category: Babon, J J]] | ||
[[Category: Bulaj, G | [[Category: Buczek, O]] | ||
[[Category: Fiedler, B | [[Category: Bulaj, G]] | ||
[[Category: Norton, R S | [[Category: Fiedler, B]] | ||
[[Category: Olivera, B M | [[Category: Norton, R S]] | ||
[[Category: Wei, D X | [[Category: Olivera, B M]] | ||
[[Category: Yang, X D | [[Category: Wei, D X]] | ||
[[Category: Yoshikami, D | [[Category: Yang, X D]] | ||
[[Category: Yoshikami, D]] | |||
[[Category: Iaa]] | [[Category: Iaa]] | ||
[[Category: Ina]] | [[Category: Ina]] | ||
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[[Category: Trifluoroacetic acid]] | [[Category: Trifluoroacetic acid]] | ||
[[Category: Vgsc]] | [[Category: Vgsc]] | ||
[[Category: Voltage-gated sodium channel | [[Category: Voltage-gated sodium channel]] | ||