2v00: Difference between revisions

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-==X-RAY CRYSTAL STRUCTURE OF ENDOTHIAPEPSIN COMPLEXED WITH COMPOUND 1==
-<StructureSection load='2v00' size='340' side='right' caption='[[2v00]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
+==X-ray crystal structure of endothiapepsin complexed with compound 1==
+<StructureSection load='2v00' size='340' side='right'caption='[[2v00]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2v00]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2V00 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2v00]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cryphonectria_parasitica Cryphonectria parasitica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V00 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=V15:2-AMINO-6-(2-PHENYLETHYL)PYRIMIDIN-4(3H)-ONE'>V15</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e5o|1e5o]], [[1e80|1e80]], [[1e81|1e81]], [[1e82|1e82]], [[1eed|1eed]], [[1ent|1ent]], [[1gkt|1gkt]], [[1gvt|1gvt]], [[1gvu|1gvu]], [[1gvv|1gvv]], [[1gvw|1gvw]], [[1gvx|1gvx]], [[1od1|1od1]], [[1oew|1oew]], [[1oex|1oex]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=V15:2-AMINO-6-(2-PHENYLETHYL)PYRIMIDIN-4(3H)-ONE'>V15</scene></td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Endothiapepsin Endothiapepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.22 3.4.23.22] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v00 OCA], [https://pdbe.org/2v00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v00 RCSB], [https://www.ebi.ac.uk/pdbsum/2v00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v00 ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v00 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v00 RCSB], [http://www.ebi.ac.uk/pdbsum/2v00 PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/CARP_CRYPA CARP_CRYPA]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v00_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v0/2v00_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v00 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2v00" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 34: / Line 37: @@
 </StructureSection>
 [[Category: Cryphonectria parasitica]]
-[[Category: Endothiapepsin]]
+[[Category: Large Structures]]
-[[Category: Albert, J S.]]
+[[Category: Albert JS]]
-[[Category: Beer, T De.]]
+[[Category: De Beer T]]
-[[Category: Deinum, J.]]
+[[Category: Deinum J]]
-[[Category: Edwards, P D.]]
+[[Category: Edwards PD]]
-[[Category: Folmer, R H.A.]]
+[[Category: Folmer RHA]]
-[[Category: Geschwindner, S.]]
+[[Category: Geschwindner S]]
-[[Category: Olsson, L L.]]
+[[Category: Olsson LL]]
-[[Category: Alzheimer's disease]]
-[[Category: Aspartyl protease]]
-[[Category: B- secretase]]
-[[Category: Bace]]
-[[Category: Endothiapepsin]]
-[[Category: Fragment hit]]
-[[Category: Fragment-based lead generation]]
-[[Category: Hydrolase]]
-[[Category: Isocytosine]]
-[[Category: Protease]]
-[[Category: Surrogate protein]]
-[[Category: Zymogen]]