1zo6: Difference between revisions
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{{Theoretical_model}} | |||
==NMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C- TERMINAL UBA DOMAIN OF HHR23A== | ==NMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C- TERMINAL UBA DOMAIN OF HHR23A== | ||
<StructureSection load='1zo6' size='340' side='right' caption='[[1zo6]]' scene=''> | <StructureSection load='1zo6' size='340' side='right'caption='[[1zo6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZO6 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zo6 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1zo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zo6 ProSAT]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1zo6" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Theoretical Model]] | |||
[[Category: Large Structures]] | |||
[[Category: Assfalg, M]] | [[Category: Assfalg, M]] | ||
[[Category: Fushman, D]] | [[Category: Fushman, D]] | ||
Latest revision as of 11:22, 10 November 2021
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NMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C- TERMINAL UBA DOMAIN OF HHR23ANMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C- TERMINAL UBA DOMAIN OF HHR23A
Structural highlights
Publication Abstract from PubMedAlthough functional diversity in polyubiquitin chain signaling has been ascribed to the ability of differently linked chains to bind in a distinctive manner to effector proteins, structural models of such interactions have been lacking. Here, we use NMR to unveil the structural basis of selective recognition of Lys48-linked di- and tetraubiquitin chains by the UBA2 domain of hHR23A. Although the interaction of UBA2 with Lys48-linked diubiquitin involves the same hydrophobic surface on each ubiquitin unit as that utilized in monoubiquitin:UBA complexes, our results show how the "closed" conformation of Lys48-linked diubiquitin is crucial for high-affinity binding. Moreover, recognition of Lys48-linked diubiquitin involves a unique epitope on UBA, which allows the formation of a sandwich-like diubiqutin:UBA complex. Studies of the UBA-tetraubiquitin interaction suggest that this mode of UBA binding to diubiquitin is relevant for longer chains. Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.,Varadan R, Assfalg M, Raasi S, Pickart C, Fushman D Mol Cell. 2005 Jun 10;18(6):687-98. PMID:15949443[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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