Tubulin: Difference between revisions

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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-{{STRUCTURE_1z5w|  PDB=1z5w  | SIZE=350| SCENE=Tubulin/Cv/1 |right|CAPTION= γ-tubulin complex with GTP (stick model) and Mg+2 ion (green), [[1z5w]] }}
+<StructureSection load='' size='350' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
+== Function ==
-[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP.  γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes.  FtsZ  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB.
+[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes.  Tubulin filaments are stabilized by taxol and zampanolide.  '''FtsZ'''  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]].
-== 3D Structures of Tubulin ==
+== Relevance ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+The chemotherapeutic drug Taxol interacts with TUBB.  See [[Molecular Playground/Taxol]].  TUBA and TUBB expression in polyps of invasive colon cancer is different from normal<ref>PMID:16101133</ref>.
-===α-tubulin===
+See [[Paclitaxel]].
-[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br />
+== Disease ==
-[[2e4h]] – hTUBA C terminal + restin CAP-Gly domain 2 – human<br />
+Mutations in TUBB underlie a large spectrum of neuronal migration disorders<ref>PMID:19465910</ref>.
-===α-tubulin + β-tubulin===
+== Structural highlights ==
+*<scene name='43/430888/Cv/6'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
-[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]], [[3n2g]], [[3n2k]], [[3ryc]], [[3ryf]], [[3ryh]], [[3ryi]] – sTUBA+sTUBB+stathmin-like protein B3 – sheep<br />
+== 3D Structures of Tubulin ==
-[[4f61]] - sTUBA+sTUBB+stathmin-like protein R4<br />
+[[Tubulin 3D Structures]]
-[[3ut5]] - sTUBA+sTUBB+stathmin-like protein B3 + vinca peptide<br />
-[[4eb6]] - sTUBA+sTUBB+stathmin-4<br />
-[[4drx]] - sTUBA+sTUBB + ankyrin repeat protein<br />
-[[4f6r]] - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein<br />
-[[2wbe]] – bTUBA1D+bTUBB2B+kinesin+AMPPNP – bovine<br />
-[[3dco]] - bTUBA+bTUBB+kinesin-like NOD<br />
-[[4ck5]], [[4kc6]], [[4kc7]] - bTUBA+bTUBB+kinesin-like KIF11 motor domain<br />
-[[1tvk]] - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
-[[3iz0]] - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy<br />
-[[3edl]] - bTUBA1D+bTUBB2B+kinesin motor domain<br />
-[[2xrp]] - bTUBA1D+bTUBB2B+doublecortin <br />
-[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]] – bTUBA1C+bTUBB2B+stathmin-like protein B3<br />
-[[1ffx]] - bTUBA+bTUBB+stathmin-like protein B3<br />
-[[4o2a]] - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase<br />
-[[4o2b]] - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + colchicine<br />
-[[4o4h]] - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + laulimalide<br />
-[[4o4i]] - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + epothilone + laulimalide<br />
-[[4o4j]] - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + peloruside<br />
-[[4o4l]] - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + peloruside + epothilone<br />
-[[1jff]] - bTUBA+bTUBB<br />
-[[4hna]] - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein<br />
-[[4ihj]] - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase + ADP<br />
-[[4iij]], [[4i55]] - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase <br />
-[[3j1t]], [[3j1u]] - bTUBA+bTUBB+ dyenin<br />
-[[3j2u]] - bTUBA+bTUBB+kinesin-like KLP10A head domain<br />
-[[4i50]], [[4i4t]] - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase + anti-cancer agent<br />
-[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br />
-[[2hxf]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig<br />
-[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
-[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
-[[4abo]] - pTUBA+pTUBB+ microtubule integrity protein MAL3<br />
-[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
-[[4aqv]], [[4aqw]] - bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM<br />
-[[4atu]] - bTUBA1D+bTUBB2B+doublecortin – Cryo EM<br />
-[[4atx]] - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM<br />
-[[2btq]] – PdTUBA+PdTUBB<br />
-[[4ffb]] - TUBA+TUBB (mutant) + protein STU2 - yeast
-===γ-tubulin===
-[[3cb2]] – hTUBG1+GDP<br />
-[[1z5v]] - hTUBG1+GTPgS<br />
-[[1z5w]] - hTUBG1+GTP<br />
-[[3rip]] – hTUBG4<br />
-=== FtsZ ===
-[[2vxy]], [[2vam]] – BsFtsZ - ''Bacillus subtilis''<br />
-[[2ve8]] – PaFtsZ gamma domain – ''Pseudomonas aeruginosa''<br />
-[[2r6r]]– AaFtsZ - ''Aquifex aeolicus''<br />
-[[1w59]], [[1fsz]] – MjFtsZ - ''Methancaldococcus jannaschii''<br />
-[[1w5e]], [[1w5f]] – MjFtsZ (mutant) <br />
-[[3v3t]] – FtsZ (mutant) – ''Clostridium botulinum''<br />
-[[3zid]] – FtsZ – ''Methanosaeta thermophila''<br />
-[[3vo9]], [[3vpa]] - SaFtsZ – ''Staphylococcus aureus''<br />
-[[3wgj]], [[3wgk]] – SaFtsZ (mutant) <br />
-===FtsZ complexes===
-[[2rhh]], [[2rhj]] – BsFtsZ+SO4 <br />
+</StructureSection>
-[[2rhl]] - BsFtsZ+GDP<br />
-[[2rho]] - BsFtsZ+GDP+GTP-gamma-S<br />
-[[2ve9]] - PaFtsZ gamma domain+DNA<br />
-[[2vaw]] – PaFtsZ+GDP<br />
-[[1ofu]] - PaFtsZ+SULA<br />
-[[2r75]] - AaFtsZ+8-morpholino-GTP <br />
-[[2q1x]], [[1rq2]] - MtFtsZ+citrate – ''Mycobacterium tuberculosis''<br />
-[[2q1y]], [[1rlu]] - MtFtsZ+GTP-gamma-S<br />
-[[1rq7]], [[4kwe]] - MtFtsZ+GDP<br />
-[[2vap]] – MjFtsZ+GDP <br />
-[[1w58]] - MjFtsZ+GMPCPP<br />
-[[1w5a]] - MjFtsZ+MgGTP<br />
-[[1w5b]] - MjFtsZ+GTP<br />
-[[4b45]] – HvFtsZ + GTP-γS – ''Haloferax volcanii''<br />
-[[3vo8]], [[3voa]] - SaFtsZ + GDP <br />
-[[3wgl]] – SaFtsZ (mutant) + GDP<br />
-[[3wgn]] – SaFtsZ + GTP-γS<br />
-[[3wgm]] – SaFtsZ (mutant) + GTP<br />
-[[3vob]] - SaFtsZ + GDP + benzamide derivative<br />
-[[4dxd]] - SaFtsZ + antibiotic <br />
-[[4b46]] - HvFtsZ + GDP <br />
-[[4m8i]] - SeFtsZ + GDP – ''Staphylococcus epidermitis''<br />
+== References ==
+<references/>
 [[Category:Topic Page]]