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==Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3==
==Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3==
<StructureSection load='1k6f' size='340' side='right' caption='[[1k6f]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='1k6f' size='340' side='right'caption='[[1k6f]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1k6f]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K6F FirstGlance]. <br>
<table><tr><td colspan='2'>[[1k6f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saimiriine_gammaherpesvirus_2 Saimiriine gammaherpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6F FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k6f RCSB], [http://www.ebi.ac.uk/pdbsum/1k6f PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6f OCA], [https://pdbe.org/1k6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6f RCSB], [https://www.ebi.ac.uk/pdbsum/1k6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6f ProSAT]</span></td></tr>
<div style="background-color:#fffaf0;">
</table>
== Publication Abstract from PubMed ==
== Function ==
The first report of the full-length structure of the collagen-like polypeptide [(Pro-Pro-Gly)(10)](3) is given. This structure was obtained from crystals grown in a microgravity environment, which diffracted up to 1.3 A, using synchrotron radiation. The final model, which was refined to an R(factor) of 0.18, is the highest-resolution description of a collagen triple helix reported to date. This structure provides clues regarding a series of aspects related to collagen triple helix structure and assembly. The strict dependence of proline puckering on the position inside the Pro-Pro-Gly triplets and the correlation between backbone and side chain dihedral angles support the propensity-based mechanism of triple helix stabilization/destabilization induced by hydroxyproline. Furthermore, the analysis of [(Pro-Pro-Gly)(10)](3) packing, which is governed by electrostatic interactions, suggests that charges may act as locking features in the axial organization of triple helices in the collagen fibrils.
[https://www.uniprot.org/uniprot/Q80BK4_SHV2 Q80BK4_SHV2]
 
Crystal structure of the collagen triple helix model [(Pro-Pro-Gly)(10)](3).,Berisio R, Vitagliano L, Mazzarella L, Zagari A Protein Sci. 2002 Feb;11(2):262-70. PMID:11790836<ref>PMID:11790836</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


==See Also==
==See Also==
*[[Collagen|Collagen]]
*[[Collagen 3D structures|Collagen 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Berisio, R.]]
[[Category: Large Structures]]
[[Category: Mazzarella, L.]]
[[Category: Saimiriine gammaherpesvirus 2]]
[[Category: Vitagliano, L.]]
[[Category: Berisio R]]
[[Category: Zagari, A]]
[[Category: Mazzarella L]]
[[Category: Amino acid preference]]
[[Category: Vitagliano L]]
[[Category: Collagen stability]]
[[Category: Zagari A]]
[[Category: Puckering]]
[[Category: Structural protein]]
[[Category: Triple helix]]

Latest revision as of 10:44, 7 February 2024

Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3Crystal Structure of the Collagen Triple Helix Model [(Pro-Pro-Gly)10]3

Structural highlights

1k6f is a 6 chain structure with sequence from Saimiriine gammaherpesvirus 2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q80BK4_SHV2

See Also

1k6f, resolution 1.30Å

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