Growth factor receptor-bound protein: Difference between revisions

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Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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-<StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold)  (PDB entry [[1tze]])' scene=''>
+<StructureSection load='' size='350' side='right' caption='Structure of human Grb2 SH2 domain (green) complex with phosphotyrosyl polypeptide (magenta)  (PDB entry [[1bmb]])' scene='51/516448/Cv/1'>
+== Function ==
 '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins.  GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br />
-*  '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases.  GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences.  GRB2 is involved in signal transduction.<br />
+*  '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases.  GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences.  GRB2 is involved in signal transduction<ref>PMID:1322798</ref>.<br />
-*  '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.<br />
+*  '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway<ref>PMID:19717535</ref>.<br />
-*  '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors.  For additional details on GRB10 see [[Grb10 SH2 Domain]].<br />
+*  '''GRB10''' and '''GRB14''' interact with insulin receptor and insulin-like growth factor receptors<ref>PMID:12783867</ref>.  For additional details on GRB10 see [[Grb10 SH2 Domain]].<br />
-==3D structures of Grb==
+== Structural highlights ==
+Human GRB2 residue <scene name='51/516448/Cv/5'>Trp121 forces the phosphotyrosyl containing ligand</scene> into a turn conformation. Water molecules are shown as red spheres. <scene name='51/516448/Cv/6'>Phosphotyrosine binding</scene>  <ref>PMID:10090780</ref>.
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+==3D structures of growth factor receptor-bound proteins==
+[[Growth factor receptor-bound proteins 3D structures]]
-===GRB2===
+</StructureSection>
-[[1gri]], [[2h46]] – hGRB2 – human <br />
-''GRB2 C terminal SH3 domain''
-[[1gfc]], [[1gfd]] – hGRB2 C terminal SH3 domain - NMR<br />
-[[2vvk]], [[2vwf]], [[2w0z]] – hGRB2 C terminal SH3 domain <br />
-[[1io6]] – hGRB2 C terminal SH3 domain + ligand peptide - NMR<br />
-[[1gcq]] – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain<br />
-''GRB2 N terminal SH3 domain''
-[[1gbr]], [[1gbq]], [[2gbq]], [[3gbq]], [[4gbq]] – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR<br />
-[[1aze]] – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR<br />
-''GRB2 SH2 domain''
-[[1jyu]] – hGRB2 SH2 domain <br />
-[[1ghu]] – hGRB2 SH2 domain (mutant) - NMR<br />
-[[1fhs]] – hGRB2 SH2 domain - NMR<br />
-[[1x0n]] – hGRB2 SH2 domain + inhibitor - NMR<br />
-[[2huw]] – hGRB2 SH2 domain + cyclopropane derivative<br />
-[[1cj1]] – hGRB2 SH2 domain + phosphor-Tyr derivative<br />
-[[2aoa]], [[2aob]] – hGRB2 SH2 domain + peptide mimetic<br />
-[[1tze]], [[1bmb]], [[1bm2]], [[1zfp]], [[1fyr]], [[1jyq]], [[1jyr]], [[2h5k]], [[3c7i]], [[3imd]], [[3imj]], [[3in7]], [[3in8]], [[3kfj]], [[3n8m]], [[3n7y]], [[3n84]], [[3mxc]], [[3mxy]], [[3ov1]], [[3ove]], [[3s8l]], [[3s8n]], [[3s8o]], [[1zfp]] – hGRB2 SH2 domain + phosphor-Tyr peptide<br />
-[[1qg1]] – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR<br />
-[[3wa4]] - hGRB2 SH2 domain + CD28 peptide <br />
-===GRB4===
-[[4e6r]] – hGRB4 C terminal SH3 domain <br />
-===GRB7===
-[[2qms]] – hGRB7 SH2 domain <br />
-[[1mw4]], [[2l4k]] – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR<br />
-[[3pqz]] – hGRB7 SH2 domain + cyclic peptide <br />
-[[1wgr]] – hGRB7 RA domain - NMR<br />
-===GRB10===
-[[1nrv]] – hGRB10 SH2 domain <br />
-[[3m7f]] – hGRB10 SH2 domain + NEDD4 C2 domain<br />
-[[3hk0]] – hGRB10 RA and PH domains <br />
-===GRB14===
-[[2aug]] – hGRB14 SH2 domain <br />
-[[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br />
-[[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br />
+== References ==
+<references/>
 [[Category:Topic Page]]