4oo1: Difference between revisions

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 ==Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA==
-<StructureSection load='4oo1' size='340' side='right' caption='[[4oo1]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
+<StructureSection load='4oo1' size='340' side='right'caption='[[4oo1]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4oo1]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OO1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4oo1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OO1 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oo1 RCSB], [http://www.ebi.ac.uk/pdbsum/4oo1 PDBsum]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<table>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4oo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oo1 OCA], [https://pdbe.org/4oo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4oo1 RCSB], [https://www.ebi.ac.uk/pdbsum/4oo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4oo1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CSL4_YEAST CSL4_YEAST] Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.<ref>PMID:10465791</ref> <ref>PMID:17173052</ref> <ref>PMID:19060898</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4oo1" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Exosome 3D structures|Exosome 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Lima, C D.]]
+[[Category: Large Structures]]
-[[Category: Wasmuth, E V.]]
+[[Category: Saccharomyces cerevisiae S288C]]
-[[Category: Hydrolase-rna complex]]
+[[Category: Lima CD]]
-[[Category: Nucleus]]
+[[Category: Wasmuth EV]]
-[[Category: Rna binding protein-rna complex]]
-[[Category: Rna exosome complex]]
-[[Category: Rna processing/decay]]