4ur3: Difference between revisions

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-'''Unreleased structure'''
-The entry 4ur3 is ON HOLD  until Paper Publication
+==Crystal structure of the PCE reductive dehalogenase from S. multivorans P2(1) crystal form==
+<StructureSection load='4ur3' size='340' side='right'caption='[[4ur3]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ur3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurospirillum_multivorans Sulfurospirillum multivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UR3 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.235&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BVQ:NORPSEUDO-B12'>BVQ</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ur3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ur3 OCA], [https://pdbe.org/4ur3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ur3 RCSB], [https://www.ebi.ac.uk/pdbsum/4ur3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ur3 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Organohalide-respiring microorganisms can use a variety of persistent pollutants including trichloroethene (TCE) as terminal electron acceptors. The final two-electron transfer step in organohalide respiration is catalyzed by reductive dehalogenases. Here we report the x-ray crystal structure of PceA, an archetypal dehalogenase from Sulfurospirillum multivorans, as well as structures of PceA in complex with TCE and product analogs. The active site harbors a deeply buried norpseudo-B12 cofactor within a nitroreductase fold, also found in a mammalian B12 chaperone. The structures of PceA reveal how a cobalamin supports a reductive haloelimination exploiting a conserved B12-binding scaffold capped by a highly variable substrate-capturing region.
-Authors: Bommer, M., Kunze, C., Fesseler, J., Schubert, T., Diekert, G., Dobbek, H.
+Structural basis for organohalide respiration.,Bommer M, Kunze C, Fesseler J, Schubert T, Diekert G, Dobbek H Science. 2014 Oct 2. pii: 1258118. PMID:25278505<ref>PMID:25278505</ref>
-Description: Crystal structure of the PCE reductive dehalogenase from S. multivorans P2(1) crystal form
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4ur3" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Sulfurospirillum multivorans]]
+[[Category: Bommer M]]
+[[Category: Diekert G]]
+[[Category: Dobbek H]]
+[[Category: Fesseler J]]
+[[Category: Kunze C]]
+[[Category: Schubert T]]