Formyl-CoA transferase: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='2vjo' size='340' side='right' caption='Structure of formyl-CoA transferase complex with oxalate and CoA (PDB code 2yjo).' scene=''> '''Formyl-CoA transferase'... |
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<StructureSection load='' size='350' side='right' caption='Structure of formyl-CoA transferase complex with oxalate, CoA, HEPES buffer and Cl- ion (green) (PDB code [[2vjo]]).' scene='59/593959/Cv/1'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''Formyl-CoA transferase''' (FCT) catalyzes the conversion of formyl-CoA and oxalate to formate and oxalyl-CoA. FCT takes part in the oxalate degradation pathway<ref>PMID:12839984</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
FCT structure shows <scene name='59/593959/Cv/2'>2 domains: large and small</scene>. The large domain is composed of residues from the N-terminal and the C-terminal. The active site binds <scene name='59/593959/Cv/10'>oxalate</scene>, <scene name='59/593959/Cv/11'>Cl</scene> and <scene name='59/593959/Cv/12'>CoA</scene> <ref>PMID:18162462</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | |||
==3D structures of formyl-CoA transferase== | ==3D structures of formyl-CoA transferase== | ||
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[[1p5h]] – OfFCT – ''Oxalobacter formigenes''<br /> | [[1p5h]] – OfFCT – ''Oxalobacter formigenes''<br /> | ||
[[1t3z]], [[2vjn]], [[2vjp]], [[2vjq]] – OfFCT (mutant)<br /> | [[1t3z]], [[2vjn]], [[2vjp]], [[2vjq]] – OfFCT (mutant)<br /> | ||
[[1p5r]], [[ | [[1p5r]], [[2vjk]], [[2vjl]] – OfFCT + CoA<br /> | ||
[[1vgq]], [[1vgr]] – OfFCT (mutant) + CoA<br /> | [[1vgq]], [[1vgr]] – OfFCT (mutant) + CoA<br /> | ||
[[1t4c]] – OfFCT + oxalyl-aspartyl anhydride + CoA<br /> | [[1t4c]] – OfFCT + oxalyl-aspartyl anhydride + CoA<br /> | ||