Intercellular adhesion molecule: Difference between revisions

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<StructureSection load='1mq8' size='340' side='right' caption='Structure of human ICAM-1 domains 1-2 (grey and pink) complex with LFA-1 (yellow and green) and Mg+2 ion (green) (PDB code [[1mq8]]).' scene=''>
<StructureSection load='1mq8' size='340' side='right' caption='Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code [[1mq8]]).' scene=''>


== Function ==
== Function ==


'''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily.  ICAM binds to LFA-1 and macrophage-1 antigen during inflammation.  ICAM contains 5 Ig-like domains.
'''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily.  ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation<ref>PMID:8834767</ref>.  ICAM contains 5 Ig-like domains.
 
*'''ICAM-1''' is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
*'''ICAM-2''' mediates adhesive interactions important for antigen-specific immune response.
*'''ICAM-3''' acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils<ref>PMID:23775590</ref>.
*'''ICAM-5''' has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes.


== Disease ==
== Disease ==
ICAM mutation is involved in multiple sclerosis<ref>PMID:12590979</ref>.


== Relevance ==
</StructureSection>
 
== Structural highlights ==


==3D structures of intercellular adhesion molecule==
==3D structures of intercellular adhesion molecule==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===ICAM-1 (CD54)===
*ICAM-1 (CD54)
 
[[1iam]], [[1ic1]], [[1d3l]] – hICAM N terminal domain – human<br />
[[1p53]] – hICAM domain 3-5<br />


''ICAM-1 complexes''
**[[1iam]], [[1ic1]], [[1d3l]] – hICAM N terminal domain – human<br />
**[[1p53]] – hICAM domain 3-5<br />


[[1d3e]], [[1d3i]] – hICAM N terminal domain + rhinovirus coat proteins - CryoEM<br />
*ICAM-1 complexes
[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
[[3tcx]] – hICAM domain 1 + LFA-1<br />
[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
[[2qz4]] – hICAM domain 4 + antibody<br />


===ICAM-2===
**[[1d3e]], [[1d3i]] – hICAM N terminal domain + rhinovirus coat proteins - CryoEM<br />
**[[7bg7]] – hICAM + rhinovirus polyproteins - CryoEM<br />
**[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
**[[3tcx]] – hICAM domain 1 + LFA-1<br />
**[[6eit]] – hICAM domain 1-2 + coxsakievirus coat proteins - CryoEM<br />
**[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
**[[2oz4]] – hICAM domain 4 + antibody<br />
**[[5mza]], [[6s8u]] – hICAM residues 28-212 + erythrocyte membrane protein 1<br />


[[1zxq]] – hICAM extracellular domain <br />
*ICAM-2


===ICAM-3===
**[[1zxq]] – hICAM extracellular domain <br />


[[1t0p]] – hICAM N terminal domain + LFA-1<br />
*ICAM-3


===ICAM-5===
**[[1t0p]] – hICAM N terminal domain + LFA-1<br />


[[3bn3]] – hICAM N terminal domain + LFA-1<br />
*ICAM-5


**[[3bn3]] – hICAM N terminal domain + LFA-1<br />
**[[4oi9]], [[4oia]], [[4oib]] – hICAM domain D1-D4<br />
}}


== References ==
== References ==

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Michal Harel
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