1yu2: Difference between revisions
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==Major Tropism Determinant M1 Variant== | ==Major Tropism Determinant M1 Variant== | ||
<StructureSection load='1yu2' size='340' side='right' caption='[[1yu2]], [[Resolution|resolution]] 1.86Å' scene=''> | <StructureSection load='1yu2' size='340' side='right'caption='[[1yu2]], [[Resolution|resolution]] 1.86Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yu2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1yu2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_phage_BMP-1 Bordetella phage BMP-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YU2 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yu2 OCA], [https://pdbe.org/1yu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yu2 RCSB], [https://www.ebi.ac.uk/pdbsum/1yu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yu2 ProSAT]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FIBD_BPBPP FIBD_BPBPP] Tail fiber protein located at the distal ends of the fibers that binds to the adhesion receptors on the host surface, thereby determining the host range. The phage can alter its tropism by modifying this protein. Variants are expressed through a diversity-generating retroelement (DGR) that creates mutant copies of a template repeat and replaces the end of the tail fiber receptor-binding protein with these sequences, thus changing the host range. Milliards of variants of the fiber receptor-binding protein can be created with this system.<ref>PMID:15386016</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1yu2" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bordetella phage | [[Category: Bordetella phage BMP-1]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ghosh P]] | ||
[[Category: | [[Category: Lawton JA]] | ||
[[Category: | [[Category: McMahon SA]] | ||
[[Category: | [[Category: Miller JL]] | ||