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==Complex structure of HEVB EV93 main protease 3C with Compound 1 (AG7404)==
==Complex structure of HEVB EV93 main protease 3C with Compound 1 (AG7404)==
<StructureSection load='3q3y' size='340' side='right' caption='[[3q3y]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
<StructureSection load='3q3y' size='340' side='right'caption='[[3q3y]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q3y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_enterovirus_b Human enterovirus b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q3Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterovirus_B Enterovirus B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q3Y FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PI:HYDROGENPHOSPHATE+ION'>PI</scene>, <scene name='pdbligand=XNV:ETHYL+(4R)-4-({(2S)-2-[3-{[(5-METHYL-1,2-OXAZOL-3-YL)CARBONYL]AMINO}-2-OXOPYRIDIN-1(2H)-YL]PENT-4-YNOYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE'>XNV</scene><br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q3x|3q3x]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=PI:HYDROGENPHOSPHATE+ION'>PI</scene>, <scene name='pdbligand=XNV:ETHYL+(4R)-4-({(2S)-2-[3-{[(5-METHYL-1,2-OXAZOL-3-YL)CARBONYL]AMINO}-2-OXOPYRIDIN-1(2H)-YL]PENT-4-YNOYL}AMINO)-5-[(3S)-2-OXOPYRROLIDIN-3-YL]PENTANOATE'>XNV</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">3C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=138949 Human enterovirus B])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3y OCA], [https://pdbe.org/3q3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q3y RCSB], [https://www.ebi.ac.uk/pdbsum/3q3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q3y ProSAT]</span></td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Picornain_3C Picornain 3C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.28 3.4.22.28] </span></td></tr>
</table>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q3y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q3y RCSB], [http://www.ebi.ac.uk/pdbsum/3q3y PDBsum]</span></td></tr>
== Function ==
<table>
[https://www.uniprot.org/uniprot/Q5DSM6_9ENTO Q5DSM6_9ENTO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Structural basis for antiviral inhibition of the main protease 3C from human enterovirus 93.,Costenaro L, Kaczmarska Z, Arnan C, Janowski R, Coutard B, Sola M, Gorbalenya AE, Norder H, Canard B, Coll M J Virol. 2011 Aug 10. PMID:21835784<ref>PMID:21835784</ref>
Structural basis for antiviral inhibition of the main protease 3C from human enterovirus 93.,Costenaro L, Kaczmarska Z, Arnan C, Janowski R, Coutard B, Sola M, Gorbalenya AE, Norder H, Canard B, Coll M J Virol. 2011 Aug 10. PMID:21835784<ref>PMID:21835784</ref>


From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3q3y" style="background-color:#fffaf0;"></div>
==See Also==
*[[Virus protease 3D structures|Virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human enterovirus b]]
[[Category: Enterovirus B]]
[[Category: Picornain 3C]]
[[Category: Large Structures]]
[[Category: Arnan, C.]]
[[Category: Arnan C]]
[[Category: Canard, B.]]
[[Category: Canard B]]
[[Category: Coll, M.]]
[[Category: Coll M]]
[[Category: Costenaro, L.]]
[[Category: Costenaro L]]
[[Category: Coutard, B.]]
[[Category: Coutard B]]
[[Category: Kaczmarska, Z.]]
[[Category: Kaczmarska Z]]
[[Category: Norder, H.]]
[[Category: Norder H]]
[[Category: Sola, M.]]
[[Category: Sola M]]
[[Category: Cysteine trypsin-like protease]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

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